eprintid: 1459193
rev_number: 35
eprint_status: archive
userid: 608
dir: disk0/01/45/91/93
datestamp: 2014-12-22 22:41:28
lastmod: 2021-10-04 01:56:57
status_changed: 2016-06-01 14:50:35
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Kucuk, I
creators_name: Edirisinghe, M
title: Microfluidic preparation of polymer nanospheres
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F45
keywords: Microfluidics, Nanobiotechnology, Nanocarriers, Nanopheres, Perfluorohexane, Polymethylsilsesquioxane, Surface morphology
note: © The Author(s) 2014 
Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
abstract: In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfluorohexane using the other channel. The mechanism by which the nanospheres are generated is explained using high speed camera imaging. The polymer concentration (5-50 wt%) and flow rates of the feeds (50-300 µl min(-1)) were important parameters in controlling the nanosphere diameter. The diameter of the polymer nanospheres was found to be in the range of 80-920 nm with a polydispersity index of 11-19 %. The interior structure and surfaces of the nanospheres prepared were studied using advanced microscopy and showed the presence of fine pores and cracks on surface which can be used as drug entrapment locations.
date: 2014-12
date_type: published
official_url: http://dx.doi.org/10.1007/s11051-014-2626-5
vfaculties: VENG
oa_status: green
full_text_type: pub
pmcid: PMC4255063
language: eng
primo: open
primo_central: open_green
article_type_text: JOURNAL ARTICLE
verified: verified_manual
elements_source: PubMed
elements_id: 1000173
doi: 10.1007/s11051-014-2626-5
pii: 2626
language_elements: ENG
lyricists_name: Edirisinghe, Mohan
lyricists_name: Kucuk, Israfil
lyricists_id: MJEDE48
lyricists_id: IKUCU41
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Journal of Nanoparticle Research
volume: 16
number: 12
pagerange: 2626
issn: 1388-0764
citation:        Kucuk, I;    Edirisinghe, M;      (2014)    Microfluidic preparation of polymer nanospheres.                   Journal of Nanoparticle Research , 16  (12)   p. 2626.    10.1007/s11051-014-2626-5 <https://doi.org/10.1007/s11051-014-2626-5>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1459193/1/Microfluidic%20preparation%20of%20polymer%20nanospheres.pdf