eprintid: 1458408 rev_number: 53 eprint_status: archive userid: 608 dir: disk0/01/45/84/08 datestamp: 2014-12-15 20:24:32 lastmod: 2021-10-10 22:53:17 status_changed: 2017-03-21 11:09:55 type: article metadata_visibility: show item_issues_count: 0 creators_name: Golden, HL creators_name: Nicholas, JM creators_name: Yong, KX creators_name: Downey, LE creators_name: Schott, JM creators_name: Mummery, CJ creators_name: Crutch, SJ creators_name: Warren, JD title: Auditory spatial processing in Alzheimer's disease. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F85 divisions: F86 keywords: Alzheimer’s, auditory, posterior cortical atrophy, space, voxel-based morphometry, Acoustic Stimulation, Aged, Alzheimer Disease, Auditory Perceptual Disorders, Brain Mapping, Discrimination (Psychology), Female, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Photic Stimulation, Principal Component Analysis, Sound Localization, Space Perception, Statistics as Topic note: © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: The location and motion of sounds in space are important cues for encoding the auditory world. Spatial processing is a core component of auditory scene analysis, a cognitively demanding function that is vulnerable in Alzheimer's disease. Here we designed a novel neuropsychological battery based on a virtual space paradigm to assess auditory spatial processing in patient cohorts with clinically typical Alzheimer's disease (n = 20) and its major variant syndrome, posterior cortical atrophy (n = 12) in relation to healthy older controls (n = 26). We assessed three dimensions of auditory spatial function: externalized versus non-externalized sound discrimination, moving versus stationary sound discrimination and stationary auditory spatial position discrimination, together with non-spatial auditory and visual spatial control tasks. Neuroanatomical correlates of auditory spatial processing were assessed using voxel-based morphometry. Relative to healthy older controls, both patient groups exhibited impairments in detection of auditory motion, and stationary sound position discrimination. The posterior cortical atrophy group showed greater impairment for auditory motion processing and the processing of a non-spatial control complex auditory property (timbre) than the typical Alzheimer's disease group. Voxel-based morphometry in the patient cohort revealed grey matter correlates of auditory motion detection and spatial position discrimination in right inferior parietal cortex and precuneus, respectively. These findings delineate auditory spatial processing deficits in typical and posterior Alzheimer's disease phenotypes that are related to posterior cortical regions involved in both syndromic variants and modulated by the syndromic profile of brain degeneration. Auditory spatial deficits contribute to impaired spatial awareness in Alzheimer's disease and may constitute a novel perceptual model for probing brain network disintegration across the Alzheimer's disease syndromic spectrum. date: 2015-01 official_url: http://dx.doi.org/10.1093/brain/awu337 vfaculties: VFBRS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article, Research Support, Non-U.S. Gov't verified: verified_manual elements_source: PubMed elements_id: 999278 doi: 10.1093/brain/awu337 pii: awu337 lyricists_name: Crutch, Sebastian lyricists_name: Golden, Hannah lyricists_name: Mummery, Catherine lyricists_name: Nicholas, Jennifer lyricists_name: Schott, Jonathan lyricists_name: Warren, Jason lyricists_name: Yong, Keir lyricists_id: SJCRU02 lyricists_id: HLGOL19 lyricists_id: CJMUM93 lyricists_id: JNICH85 lyricists_id: JMSCH12 lyricists_id: JDWAR75 lyricists_id: KXXYO23 full_text_status: public publication: Brain volume: 138 number: 1 pagerange: 189 - 202 event_location: England issn: 0006-8950 citation: Golden, HL; Nicholas, JM; Yong, KX; Downey, LE; Schott, JM; Mummery, CJ; Crutch, SJ; Golden, HL; Nicholas, JM; Yong, KX; Downey, LE; Schott, JM; Mummery, CJ; Crutch, SJ; Warren, JD; - view fewer <#> (2015) Auditory spatial processing in Alzheimer's disease. Brain , 138 (1) 189 - 202. 10.1093/brain/awu337 <https://doi.org/10.1093/brain%2Fawu337>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1458408/1/brain.awu337.full.pdf