eprintid: 1458105
rev_number: 37
eprint_status: archive
userid: 608
dir: disk0/01/45/81/05
datestamp: 2014-12-10 20:27:27
lastmod: 2021-09-20 00:13:43
status_changed: 2014-12-10 20:27:27
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Craig-McQuaide, A
creators_name: Akram, H
creators_name: Zrinzo, L
creators_name: Tripoliti, E
title: A review of brain circuitries involved in stuttering.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: basal ganglia, deep brain stimulation, palilalia, speech neural control, stuttering, thalamus
note: Copyright © 2014 Craig-McQuaide, Akram, Zrinzo and Tripoliti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
abstract: Stuttering has been the subject of much research, nevertheless its etiology remains incompletely understood. This article presents a critical review of the literature on stuttering, with particular reference to the role of the basal ganglia (BG). Neuroimaging and lesion studies of developmental and acquired stuttering, as well as pharmacological and genetic studies are discussed. Evidence of structural and functional changes in the BG in those who stutter indicates that this motor speech disorder is due, at least in part, to abnormal BG cues for the initiation and termination of articulatory movements. Studies discussed provide evidence of a dysfunctional hyperdopaminergic state of the thalamocortical pathways underlying speech motor control in stuttering. Evidence that stuttering can improve, worsen or recur following deep brain stimulation for other indications is presented in order to emphasize the role of BG in stuttering. Further research is needed to fully elucidate the pathophysiology of this speech disorder, which is associated with significant social isolation.
date: 2014-10-17
official_url: http://dx.doi.org/10.3389/fnhum.2014.00884
vfaculties: VFBRS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Review
verified: verified_manual
elements_source: PubMed
elements_id: 998747
doi: 10.3389/fnhum.2014.00884
language_elements: ENG
lyricists_name: Akram, Harith
lyricists_name: Tripoliti, Elina
lyricists_name: Zrinzo, Ludvic
lyricists_id: HAKRA15
lyricists_id: ETRIP70
lyricists_id: LUZRI77
full_text_status: public
publication: Front Hum Neurosci
volume: 8
article_number: 884
event_location: Switzerland
citation:        Craig-McQuaide, A;    Akram, H;    Zrinzo, L;    Tripoliti, E;      (2014)    A review of brain circuitries involved in stuttering.                   Front Hum Neurosci , 8     , Article 884.  10.3389/fnhum.2014.00884 <https://doi.org/10.3389/fnhum.2014.00884>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1458105/1/fnhum-08-00884.pdf