eprintid: 1457364
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/01/45/73/64
datestamp: 2014-12-02 20:40:36
lastmod: 2021-11-30 23:07:11
status_changed: 2014-12-02 20:40:36
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Lobo, MD
creators_name: de Belder, MA
creators_name: Cleveland, T
creators_name: Collier, D
creators_name: Dasgupta, I
creators_name: Deanfield, J
creators_name: Kapil, V
creators_name: Knight, C
creators_name: Matson, M
creators_name: Moss, J
creators_name: Paton, JF
creators_name: Poulter, N
creators_name: Simpson, I
creators_name: Williams, B
creators_name: Caulfield, MJ
title: Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension.
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA4
divisions: GA3
note: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
abstract: Resistant hypertension continues to pose a major challenge to clinicians worldwide and has serious implications for patients who are at increased risk of cardiovascular morbidity and mortality with this diagnosis. Pharmacological therapy for resistant hypertension follows guidelines-based regimens although there is surprisingly scant evidence for beneficial outcomes using additional drug treatment after three antihypertensives have failed to achieve target blood pressure. Recently there has been considerable interest in the use of endoluminal renal denervation as an interventional technique to achieve renal nerve ablation and lower blood pressure. Although initial clinical trials of renal denervation in patients with resistant hypertension demonstrated encouraging office blood pressure reduction, a large randomised control trial (Symplicity HTN-3) with a sham-control limb, failed to meet its primary efficacy end point. The trial however was subject to a number of flaws which must be taken into consideration in interpreting the final results. Moreover a substantial body of evidence from non-randomised smaller trials does suggest that renal denervation may have an important role in the management of hypertension and other disease states characterised by overactivation of the sympathetic nervous system. The Joint UK Societies does not recommend the use of renal denervation for treatment of resistant hypertension in routine clinical practice but remains committed to supporting research activity in this field. A number of research strategies are identified and much that can be improved upon to ensure better design and conduct of future randomised studies.
date: 2014-11-27
official_url: http://dx.doi.org/10.1136/heartjnl-2014-307029
vfaculties: VFPHS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: REVIEW
verified: verified_manual
elements_source: PubMed
elements_id: 996107
doi: 10.1136/heartjnl-2014-307029
pii: heartjnl-2014-307029
language_elements: ENG
lyricists_name: Deanfield, John
lyricists_name: Williams, Bryan
lyricists_id: JDEAN52
lyricists_id: BWILL10
full_text_status: public
publication: Heart
volume: 101
number: 1
pagerange: 10-16
citation:        Lobo, MD;    de Belder, MA;    Cleveland, T;    Collier, D;    Dasgupta, I;    Deanfield, J;    Kapil, V;                                 ... Caulfield, MJ; + view all <#>        Lobo, MD;  de Belder, MA;  Cleveland, T;  Collier, D;  Dasgupta, I;  Deanfield, J;  Kapil, V;  Knight, C;  Matson, M;  Moss, J;  Paton, JF;  Poulter, N;  Simpson, I;  Williams, B;  Caulfield, MJ;   - view fewer <#>    (2014)    Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension.                   Heart , 101  (1)   pp. 10-16.    10.1136/heartjnl-2014-307029 <https://doi.org/10.1136/heartjnl-2014-307029>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1457364/1/Heart-2015-Lobo-10-6.pdf