eprintid: 1457364 rev_number: 31 eprint_status: archive userid: 608 dir: disk0/01/45/73/64 datestamp: 2014-12-02 20:40:36 lastmod: 2021-11-30 23:07:11 status_changed: 2014-12-02 20:40:36 type: article metadata_visibility: show item_issues_count: 0 creators_name: Lobo, MD creators_name: de Belder, MA creators_name: Cleveland, T creators_name: Collier, D creators_name: Dasgupta, I creators_name: Deanfield, J creators_name: Kapil, V creators_name: Knight, C creators_name: Matson, M creators_name: Moss, J creators_name: Paton, JF creators_name: Poulter, N creators_name: Simpson, I creators_name: Williams, B creators_name: Caulfield, MJ title: Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA4 divisions: GA3 note: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ abstract: Resistant hypertension continues to pose a major challenge to clinicians worldwide and has serious implications for patients who are at increased risk of cardiovascular morbidity and mortality with this diagnosis. Pharmacological therapy for resistant hypertension follows guidelines-based regimens although there is surprisingly scant evidence for beneficial outcomes using additional drug treatment after three antihypertensives have failed to achieve target blood pressure. Recently there has been considerable interest in the use of endoluminal renal denervation as an interventional technique to achieve renal nerve ablation and lower blood pressure. Although initial clinical trials of renal denervation in patients with resistant hypertension demonstrated encouraging office blood pressure reduction, a large randomised control trial (Symplicity HTN-3) with a sham-control limb, failed to meet its primary efficacy end point. The trial however was subject to a number of flaws which must be taken into consideration in interpreting the final results. Moreover a substantial body of evidence from non-randomised smaller trials does suggest that renal denervation may have an important role in the management of hypertension and other disease states characterised by overactivation of the sympathetic nervous system. The Joint UK Societies does not recommend the use of renal denervation for treatment of resistant hypertension in routine clinical practice but remains committed to supporting research activity in this field. A number of research strategies are identified and much that can be improved upon to ensure better design and conduct of future randomised studies. date: 2014-11-27 official_url: http://dx.doi.org/10.1136/heartjnl-2014-307029 vfaculties: VFPHS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: REVIEW verified: verified_manual elements_source: PubMed elements_id: 996107 doi: 10.1136/heartjnl-2014-307029 pii: heartjnl-2014-307029 language_elements: ENG lyricists_name: Deanfield, John lyricists_name: Williams, Bryan lyricists_id: JDEAN52 lyricists_id: BWILL10 full_text_status: public publication: Heart volume: 101 number: 1 pagerange: 10-16 citation: Lobo, MD; de Belder, MA; Cleveland, T; Collier, D; Dasgupta, I; Deanfield, J; Kapil, V; ... Caulfield, MJ; + view all <#> Lobo, MD; de Belder, MA; Cleveland, T; Collier, D; Dasgupta, I; Deanfield, J; Kapil, V; Knight, C; Matson, M; Moss, J; Paton, JF; Poulter, N; Simpson, I; Williams, B; Caulfield, MJ; - view fewer <#> (2014) Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. Heart , 101 (1) pp. 10-16. 10.1136/heartjnl-2014-307029 <https://doi.org/10.1136/heartjnl-2014-307029>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1457364/1/Heart-2015-Lobo-10-6.pdf