TY  - JOUR
JF  - Chemical Communications
A1  - Maruani, A
A1  - Alom, S
A1  - Canavelli, P
A1  - Lee, MT
A1  - Morgan, RE
A1  - Chudasama, V
A1  - Caddick, S
ID  - discovery1457332
N2  - It has recently emerged that the succinimide linkage of a maleimide thiol addition product is fragile, which is a major issue in fields where thiol functionalisation needs to be robust. Herein we deliver a strategy that generates selective cysteine thiol labelling reagents, which are stable to hydrolysis and thiol exchange.
SN  - 1364-548X
UR  - http://dx.doi.org/10.1039/c4cc08515a
N1  - This journal is ©The Royal Society of Chemistry 2015. This Open Access Article is licensed under a
Creative Commons Attribution 3.0 Unported Licence
IS  - 25
TI  - A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates
EP  - 5282
VL  - 51
AV  - public
SP  - 5279
Y1  - 2015/03/28/
ER  -