<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1456514> .
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<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/title> "A Randomized Controlled Trial of Angiotensin-Converting Enzyme Inhibition for Skeletal Muscle Dysfunction in COPD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/abstract> "BACKGROUND:  Skeletal muscle impairment is a recognized complication of COPD, predicting mortality in severe disease. Increasing evidence implicates the renin-angiotensin system in control of muscle phenotype. We hypothesized that angiotensin-converting enzyme (ACE) inhibition would improve quadriceps function and exercise performance in COPD.\r\nMETHODS:  This double-blind, randomized placebo-controlled trial investigated the effect of the ACE inhibitor, fosinopril, on quadriceps function in patients with COPD with quadriceps weakness. Primary outcomes were change in quadriceps endurance and atrophy signaling at 3 months. Quadriceps maximum voluntary contraction (QMVC), mid-thigh CT scan of the cross-sectional area (MTCSA), and incremental shuttle walk distance (ISWD) were secondary outcomes.\r\nRESULTS:  Eighty patients were enrolled (mean [SD], 65 [8] years, FEV1 43% [21%] predicted, 53% men). Sixty-seven patients (31 fosinopril, 36 placebo) completed the trial. The treatment group demonstrated a significant reduction in systolic BP (Δ−10.5 mm Hg; 95% CI, −19.9 to −1.1; P = .03) and serum ACE activity (Δ−20.4 IU/L; 95% CI, −31.0 to −9.8; P < .001) compared with placebo. No significant between-group differences were observed in the primary end points of quadriceps endurance half-time (Δ0.5 s; 95% CI, −13.3-14.3; P = .94) or atrogin-1 messenger RNA expression (Δ−0.03 arbitrary units; 95% CI, −0.32-0.26; P = .84). QMVC improved in both groups (fosinopril: Δ1.1 kg; 95% CI, 0.03-2.2; P = .045 vs placebo: Δ3.6 kg; 95% CI, 2.1-5.0; P < .0001) with a greater increase in the placebo arm (between-group, P = .009). No change was shown in the MTCSA (P = .09) or ISWD (P = .51).\r\nCONCLUSIONS:  This randomized controlled trial found that ACE inhibition, using fosinopril for 3 months, did not improve quadriceps function or exercise performance in patients with COPD with quadriceps weakness."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/date> "2014-10-01" .
<https://discovery.ucl.ac.uk/id/document/64835> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/volume> "146" .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/issue> "4" .
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<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-07afbad66e28d49b09494c46ee4c9b31> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-07afbad66e28d49b09494c46ee4c9b31> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-92d1af69640aa076a0defe862e2b9d81> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-92d1af69640aa076a0defe862e2b9d81> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a10efde774026e90676466f118be43cc> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-a10efde774026e90676466f118be43cc> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-56d869cf169b91a2604ffa0f35e130cc> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-56d869cf169b91a2604ffa0f35e130cc> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-37077d32e75d3f288a3964e036e9ebcf> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-37077d32e75d3f288a3964e036e9ebcf> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65042987a9fa6c81d87869bd598e64ba> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-65042987a9fa6c81d87869bd598e64ba> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-28d4d6c642bbcd257735a210a1098a1e> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-28d4d6c642bbcd257735a210a1098a1e> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4cef69b8fac286d9063a27fa96d0bd35> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-4cef69b8fac286d9063a27fa96d0bd35> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3a1936688d2683b69d5a41422d69bf27> .
<https://discovery.ucl.ac.uk/id/eprint/1456514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1456514#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1456514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-3a1936688d2683b69d5a41422d69bf27> .
<https://discovery.ucl.ac.uk/id/person/ext-65042987a9fa6c81d87869bd598e64ba> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-65042987a9fa6c81d87869bd598e64ba> <http://xmlns.com/foaf/0.1/givenName> "HE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-65042987a9fa6c81d87869bd598e64ba> <http://xmlns.com/foaf/0.1/familyName> "Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-65042987a9fa6c81d87869bd598e64ba> <http://xmlns.com/foaf/0.1/name> "HE Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3a1936688d2683b69d5a41422d69bf27> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3a1936688d2683b69d5a41422d69bf27> <http://xmlns.com/foaf/0.1/givenName> "NS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3a1936688d2683b69d5a41422d69bf27> <http://xmlns.com/foaf/0.1/familyName> "Hopkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3a1936688d2683b69d5a41422d69bf27> <http://xmlns.com/foaf/0.1/name> "NS Hopkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-92d1af69640aa076a0defe862e2b9d81> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-92d1af69640aa076a0defe862e2b9d81> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-92d1af69640aa076a0defe862e2b9d81> <http://xmlns.com/foaf/0.1/familyName> "Lewis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-92d1af69640aa076a0defe862e2b9d81> <http://xmlns.com/foaf/0.1/name> "A Lewis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a10efde774026e90676466f118be43cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a10efde774026e90676466f118be43cc> <http://xmlns.com/foaf/0.1/givenName> "PB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a10efde774026e90676466f118be43cc> <http://xmlns.com/foaf/0.1/familyName> "Murphy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a10efde774026e90676466f118be43cc> <http://xmlns.com/foaf/0.1/name> "PB Murphy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cef69b8fac286d9063a27fa96d0bd35> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4cef69b8fac286d9063a27fa96d0bd35> <http://xmlns.com/foaf/0.1/givenName> "MI"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cef69b8fac286d9063a27fa96d0bd35> <http://xmlns.com/foaf/0.1/familyName> "Polkey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cef69b8fac286d9063a27fa96d0bd35> <http://xmlns.com/foaf/0.1/name> "MI Polkey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07afbad66e28d49b09494c46ee4c9b31> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-07afbad66e28d49b09494c46ee4c9b31> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07afbad66e28d49b09494c46ee4c9b31> <http://xmlns.com/foaf/0.1/familyName> "Natanek"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07afbad66e28d49b09494c46ee4c9b31> <http://xmlns.com/foaf/0.1/name> "A Natanek"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5208b26cecac5c162a3e08bb4081772a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5208b26cecac5c162a3e08bb4081772a> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5208b26cecac5c162a3e08bb4081772a> <http://xmlns.com/foaf/0.1/familyName> "Shrikrishna"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5208b26cecac5c162a3e08bb4081772a> <http://xmlns.com/foaf/0.1/name> "D Shrikrishna"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56d869cf169b91a2604ffa0f35e130cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-56d869cf169b91a2604ffa0f35e130cc> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56d869cf169b91a2604ffa0f35e130cc> <http://xmlns.com/foaf/0.1/familyName> "Hart"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56d869cf169b91a2604ffa0f35e130cc> <http://xmlns.com/foaf/0.1/name> "N Hart"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28d4d6c642bbcd257735a210a1098a1e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-28d4d6c642bbcd257735a210a1098a1e> <http://xmlns.com/foaf/0.1/givenName> "PR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28d4d6c642bbcd257735a210a1098a1e> <http://xmlns.com/foaf/0.1/familyName> "Kemp"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28d4d6c642bbcd257735a210a1098a1e> <http://xmlns.com/foaf/0.1/name> "PR Kemp"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d87a80b4e129965e5efaa8293f3a65a9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d87a80b4e129965e5efaa8293f3a65a9> <http://xmlns.com/foaf/0.1/givenName> "RJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d87a80b4e129965e5efaa8293f3a65a9> <http://xmlns.com/foaf/0.1/familyName> "Tanner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d87a80b4e129965e5efaa8293f3a65a9> <http://xmlns.com/foaf/0.1/name> "RJ Tanner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-37077d32e75d3f288a3964e036e9ebcf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-37077d32e75d3f288a3964e036e9ebcf> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-37077d32e75d3f288a3964e036e9ebcf> <http://xmlns.com/foaf/0.1/familyName> "Moxham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-37077d32e75d3f288a3964e036e9ebcf> <http://xmlns.com/foaf/0.1/name> "J Moxham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-57a08de7b26c87129ea6bbbe9c217c7e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-57a08de7b26c87129ea6bbbe9c217c7e> <http://xmlns.com/foaf/0.1/givenName> "JY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-57a08de7b26c87129ea6bbbe9c217c7e> <http://xmlns.com/foaf/0.1/familyName> "Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-57a08de7b26c87129ea6bbbe9c217c7e> <http://xmlns.com/foaf/0.1/name> "JY Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
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