eprintid: 1456508 rev_number: 34 eprint_status: archive userid: 608 dir: disk0/01/45/65/08 datestamp: 2014-11-21 20:33:52 lastmod: 2021-10-04 00:49:40 status_changed: 2014-11-21 20:33:52 type: article metadata_visibility: show item_issues_count: 0 creators_name: Pillidge, K creators_name: Porter, AJ creators_name: Vasili, T creators_name: Heal, DJ creators_name: Stanford, SC title: Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice. ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 keywords: 5-Choice Serial Reaction-Time Task, Atomoxetine, Attention Deficit Hyperactivity Disorder, Hyperactivity, Impulsivity, NK1R(−/−) ‘knockout’ mouse note: © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). abstract: Mice with functional ablation of the neurokinin-1 receptor gene (NK1R(-/-)) display behavioural abnormalities which resemble the hyperactivity, inattention and impulsivity seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the established ADHD treatment, atomoxetine, alleviates these abnormalities when tested in the light/dark exploration box (LDEB) and 5-Choice Serial Reaction-Time Task (5-CSRTT). date: 2014-12 official_url: http://dx.doi.org/10.1016/j.pbb.2014.10.008 vfaculties: VFLS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article, Research Support, Non-U.S. Gov't verified: verified_manual elements_source: PubMed elements_id: 994319 doi: 10.1016/j.pbb.2014.10.008 pii: S0091-3057(14)00282-2 lyricists_name: Stanford, Susan lyricists_id: SCSTA01 full_text_status: public publication: Pharmacol Biochem Behav volume: 127 pagerange: 56 - 61 event_location: United States citation: Pillidge, K; Porter, AJ; Vasili, T; Heal, DJ; Stanford, SC; (2014) Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice. Pharmacol Biochem Behav , 127 56 - 61. 10.1016/j.pbb.2014.10.008 <https://doi.org/10.1016/j.pbb.2014.10.008>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1456508/1/1-s2.0-S0091305714002822-main.pdf