eprintid: 1456508
rev_number: 34
eprint_status: archive
userid: 608
dir: disk0/01/45/65/08
datestamp: 2014-11-21 20:33:52
lastmod: 2021-10-04 00:49:40
status_changed: 2014-11-21 20:33:52
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Pillidge, K
creators_name: Porter, AJ
creators_name: Vasili, T
creators_name: Heal, DJ
creators_name: Stanford, SC
title: Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
keywords: 5-Choice Serial Reaction-Time Task, Atomoxetine, Attention Deficit Hyperactivity Disorder, Hyperactivity, Impulsivity, NK1R(−/−) ‘knockout’ mouse
note: © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/3.0/).
abstract: Mice with functional ablation of the neurokinin-1 receptor gene (NK1R(-/-)) display behavioural abnormalities which resemble the hyperactivity, inattention and impulsivity seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the established ADHD treatment, atomoxetine, alleviates these abnormalities when tested in the light/dark exploration box (LDEB) and 5-Choice Serial Reaction-Time Task (5-CSRTT).
date: 2014-12
official_url: http://dx.doi.org/10.1016/j.pbb.2014.10.008
vfaculties: VFLS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Research Support, Non-U.S. Gov't
verified: verified_manual
elements_source: PubMed
elements_id: 994319
doi: 10.1016/j.pbb.2014.10.008
pii: S0091-3057(14)00282-2
lyricists_name: Stanford, Susan
lyricists_id: SCSTA01
full_text_status: public
publication: Pharmacol Biochem Behav
volume: 127
pagerange: 56 - 61
event_location: United States
citation:        Pillidge, K;    Porter, AJ;    Vasili, T;    Heal, DJ;    Stanford, SC;      (2014)    Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice.                   Pharmacol Biochem Behav , 127    56 - 61.    10.1016/j.pbb.2014.10.008 <https://doi.org/10.1016/j.pbb.2014.10.008>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1456508/1/1-s2.0-S0091305714002822-main.pdf