%C United States
%X Mice with functional ablation of the neurokinin-1 receptor gene (NK1R(-/-)) display behavioural abnormalities which resemble the hyperactivity, inattention and impulsivity seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the established ADHD treatment, atomoxetine, alleviates these abnormalities when tested in the light/dark exploration box (LDEB) and 5-Choice Serial Reaction-Time Task (5-CSRTT).
%O © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/3.0/).
%K 5-Choice Serial Reaction-Time Task, Atomoxetine, Attention Deficit Hyperactivity Disorder, Hyperactivity, Impulsivity, NK1R(−/−) ‘knockout’ mouse
%J Pharmacol Biochem Behav
%L discovery1456508
%P 56 - 61
%D 2014
%T Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice.
%V 127
%A K Pillidge
%A AJ Porter
%A T Vasili
%A DJ Heal
%A SC Stanford