eprintid: 1451364
rev_number: 53
eprint_status: archive
userid: 608
dir: disk0/01/45/13/64
datestamp: 2014-10-13 19:12:00
lastmod: 2021-12-20 00:40:26
status_changed: 2017-07-04 14:33:02
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Basatemur, E
creators_name: Sutcliffe, A
title: Incidence of Hypocalcemic Seizures Due to Vitamin D Deficiency in Children in the United Kingdom and Ireland
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G25
keywords: vitamin d deficiency,  
 seizures,  
 child,  
 ethnic group,  
 infant,  
 ireland,  
 pediatrics,  
 signs and symptoms,  
 asian,  
 cisplatin/dacarbazine/vinblastine protocol
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: CONTEXT: Anecdotal reports suggest that increasing numbers of children in the UK are presenting with clinical manifestations of vitamin D deficiency (VDD). However, the epidemiology of symptomatic VDD is largely undetermined; existing studies are limited to local case series, and national incidence estimates of disease burden are lacking.
OBJECTIVE: To estimate the incidence of hypocalcaemic seizures secondary to VDD in children in the UK and Ireland, and describe the demographic and clinical features of cases.
DESIGN AND SETTING: Prospective, population-based active surveillance study using the established British Paediatric Surveillance Unit (BPSU) methodology.
POPULATION: Children aged 0–15 years, resident in the UK and Ireland, who developed a hypocalcaemic seizure due to VDD between September 2011 and September 2013.
Main Outcome Measure:
Overall incidence of hypocalcaemic seizures due to VDD in children age 0–15, and incidence stratified by age, sex, and ethnicity.
RESULTS: Ninety one confirmed or probable cases were reported, equating to an overall annual incidence of 3.49 per million children age 0–15 years (95% CI: 2.81–4.26). Incidence was significantly greater in males compared to females, in infants compared to older children, and in children of South Asian or Black ethnicity compared to children from white ethnic backgrounds.
CONCLUSIONS: Current implementation of public health policy in the UK is not successful in preventing children from developing one of the severe manifestations of VDD. Further studies are required to evaluate the epidemiology of symptomatic VDD more broadly in order to guide future public health policy decisions.
date: 2015-01-01
publisher: ENDOCRINE SOC
official_url: http://dx.doi.org/ 10.1210/jc.2014-2773
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_source: PubMed
elements_id: 984939
doi: 10.1210/jc.2014-2773
lyricists_name: Basatemur, Emre
lyricists_name: Sutcliffe, Alastair
lyricists_id: EDBAS07
lyricists_id: AGSUT16
full_text_status: public
publication: Journal of Clinical Endocrinology & Metabolism
volume: 100
number: 1
pagerange: E91-E95
pages: 5
issn: 1945-7197
citation:        Basatemur, E;    Sutcliffe, A;      (2015)    Incidence of Hypocalcemic Seizures Due to Vitamin D Deficiency in Children in the United Kingdom and Ireland.                   Journal of Clinical Endocrinology & Metabolism , 100  (1)   E91-E95.    10.1210/jc.2014-2773 <https://doi.org/10.1210/jc.2014-2773>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1451364/1/Basatemur_Incident_Hypocalcemic_seizures.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/1451364/6/Basatemur_Incident_Hypocalcemic_seizures_Suppl_combined.pdf