eprintid: 1446484
rev_number: 8
eprint_status: archive
userid: 636
dir: disk0/01/44/64/84
datestamp: 2017-10-31 13:36:07
lastmod: 2017-10-31 13:36:07
status_changed: 2017-10-31 13:36:07
type: thesis
metadata_visibility: show
item_issues_count: 0
creators_name: Stanton, Michael
title: Colonic dysmotility in children
ispublished: unpub
note: Thesis digitised by ProQuest.
abstract: The literature review of this thesis describes the development, structure and function of the enteric nervous system and the known congenital anomalies, which can cause colonic dysmotility. The clinical investigations used to assess children with idiopathic chronic constipation are outlined, together with the medical and surgical therapies used in the treatment of this condition. Four studies are reported, the first of which is a retrospective review of 101 scintigraphic studies of colonic transit in the investigation of children with idiopathic chronic constipation. Second, an in vitro study of neuromuscular transmission in colonic circular muscle from adults (with carcinoma) and children with slow colonic transit (defined on radio-isotope study) is described. Third, a retrospective review of the clinical outcome of 11 children with severe slow-transit constipation in whom laparoscopic formation of an appendicostomy for colonic washouts has been carried out is reported. The fourth study is series of 7 children in whom per-appendicostomy insertion of a catheter and subsequent 24-hour studies of multipoint colonic manometry was undertaken. The results of these studies are then discussed to explain the possible implications in relation to the knowledge of the aetiology, clinical investigation and management of children with colonic dysmotility. The overall hypothesis of this thesis is that children with idiopathic chronic constipation have identifiable physiological abnormalities in colonic motor function, which may be due to enteric neuronal abnormalities.
date: 2005
id_number: PQ ETD:602409
oa_status: green
full_text_type: other
thesis_class: doctoral_open
thesis_award: Ph.D
language: eng
thesis_view: UCL_Thesis
primo: open
primo_central: open_green
verified: verified_manual
full_text_status: public
pages: 226
institution: UCL (University College London)
department: Institute of Child Health
thesis_type: Doctoral
citation:        Stanton, Michael;      (2005)    Colonic dysmotility in children.                   Doctoral thesis  (Ph.D), UCL (University College London).     Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1446484/1/Stanton.Michael_thesis.pdf