eprintid: 1443263
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/01/44/32/63
datestamp: 2014-08-28 18:44:26
lastmod: 2021-10-12 21:55:35
status_changed: 2014-08-28 18:44:26
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Wang, Y
creators_name: Goodfellow, M
creators_name: Taylor, PN
creators_name: Baier, G
title: Dynamic mechanisms of neocortical focal seizure onset.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
note: © 2014 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PMCID: PMC4133160
abstract: Recent experimental and clinical studies have provided diverse insight into the mechanisms of human focal seizure initiation and propagation. Often these findings exist at different scales of observation, and are not reconciled into a common understanding. Here we develop a new, multiscale mathematical model of cortical electric activity with realistic mesoscopic connectivity. Relating the model dynamics to experimental and clinical findings leads us to propose three classes of dynamical mechanisms for the onset of focal seizures in a unified framework. These three classes are: (i) globally induced focal seizures; (ii) globally supported focal seizures; (iii) locally induced focal seizures. Using model simulations we illustrate these onset mechanisms and show how the three classes can be distinguished. Specifically, we find that although all focal seizures typically appear to arise from localised tissue, the mechanisms of onset could be due to either localised processes or processes on a larger spatial scale. We conclude that although focal seizures might have different patient-specific aetiologies and electrographic signatures, our model suggests that dynamically they can still be classified in a clinically useful way. Additionally, this novel classification according to the dynamical mechanisms is able to resolve some of the previously conflicting experimental and clinical findings.
date: 2014-08-14
official_url: http://dx.doi.org/10.1371/journal.pcbi.1003787
vfaculties: VFLS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 971888
doi: 10.1371/journal.pcbi.1003787
pii: PCOMPBIOL-D-13-01706
lyricists_name: Baier, Gerold
lyricists_id: GBAIE50
full_text_status: public
publication: PLoS Comput Biol
volume: 10
number: 8
article_number: e1003787
event_location: United States
citation:        Wang, Y;    Goodfellow, M;    Taylor, PN;    Baier, G;      (2014)    Dynamic mechanisms of neocortical focal seizure onset.                   PLoS Comput Biol , 10  (8)    , Article e1003787.  10.1371/journal.pcbi.1003787 <https://doi.org/10.1371/journal.pcbi.1003787>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1443263/1/journal.pcbi.1003787.pdf