@article{discovery1437083,
          volume = {14},
           month = {August},
          number = {8},
         journal = {Crystal Growth \& Design},
            year = {2014},
           title = {An investigation into the dehydration behavior of Paroxetine HCl Form I using a combination of thermal and diffraction methods: the identification and characterization of a new anhydrous form},
           pages = {3774 -- 3782},
            note = {This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium,
provided the author and source are cited. https://creativecommons.org/licenses/by/4.0/},
          author = {Pina, MF and Zhao, M and Pinto, JF and Sousa, JJ and Frampton, CS and Diaz, V and Suleiman, O and F{\'a}bi{\'a}n, L and Craig, DQM},
        abstract = {Paroxetine HCl can exist as a nonstoichiometric hydrate (Form II) or as a stoichiometric hemihydrate (Form I); the latter is considered to be the stable form and its structure is well-known. However, little work has been performed to investigate its dehydration behavior; hence, the generation of the anhydrous form via dehydration of Form I was investigated. A combination of thermal (differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA)) and diffraction (variable-temperature X-ray powder diffraction (VT-XRPD)) techniques was used. Dehydrated Form I was prepared using ultradry conditions, and the resulting product was compared to dehydrated Form II. DSC indicated that the two dehydrated forms of Forms I and II had distinct melting points. TGA experiments allowed the calculation of the activation energy for the dehydration of Form I, which varies between 86 and 114 kJ/mol. Pawley refinement of the VT-XRPD data suggested that Form I dehydrates to an isostructural anhydrate, since the unit cell parameters of this new form were very similar to those of Form I with only a smaller volume as a consequence of dehydration. Comparison with dehydrated Form II indicated that these two forms represent different crystal entities; hence, a new anhydrous form of paroxetine HCl has been identified.},
             url = {https://doi.org/10.1021/cg500150r},
            issn = {1528-7483}
}