eprintid: 1437058
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/01/43/70/58
datestamp: 2014-08-09 18:34:45
lastmod: 2021-09-20 00:07:49
status_changed: 2016-04-14 16:45:45
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Verdi, J
creators_name: Tan, A
creators_name: Shoae-Hassani, A
creators_name: Seifalian, AM
title: Endometrial stem cells in regenerative medicine
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
keywords: Endometrial regenerative cells, Endometrial stem cells, Endometrium, Menstrual blood stem cells, Regenerative medicine
note: Copyright © Verdi et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
abstract: First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in regenerative medicine. EnSCs can be used as immuno-modulatory agents to attenuate inflammation, are implicated in angiogenesis and vascularization during tissue regeneration, and can also be reprogrammed into induced pluripotent stem cells. Furthermore, EnSCs can be used in tissue engineering applications and there are several clinical trials currently in place to ascertain the therapeutic potential of EnSCs. This review highlights the progress made in EnSC research, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo.
date: 2014-08-01
official_url: http://dx.doi.org/10.1186/1754-1611-8-20
vfaculties: VGHCSCI
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 968003
doi: 10.1186/1754-1611-8-20
pii: 1754-1611-8-20
lyricists_name: Seifalian, Alexander
lyricists_id: AMSEI62
full_text_status: public
publication: Journal of Biological Engineering
volume: 8
article_number: 20
event_location: England
issn: 1754-1611
citation:        Verdi, J;    Tan, A;    Shoae-Hassani, A;    Seifalian, AM;      (2014)    Endometrial stem cells in regenerative medicine.                   Journal of Biological Engineering , 8     , Article 20.  10.1186/1754-1611-8-20 <https://doi.org/10.1186/1754-1611-8-20>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1437058/1/Endometrial%20stem%20cells%20in%20regenerative%20medicine.pdf