eprintid: 1434836
rev_number: 35
eprint_status: archive
userid: 608
dir: disk0/01/43/48/36
datestamp: 2014-07-16 19:43:27
lastmod: 2021-09-29 22:19:11
status_changed: 2014-07-16 19:43:27
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Rieubland, S
creators_name: Roth, A
creators_name: Häusser, M
title: Structured connectivity in cerebellar inhibitory networks
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G95
keywords: Action Potentials, Animals, Cerebellum, Interneurons, Nerve Net, Neural Pathways, Rats, Synapses
note: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Defining the rules governing synaptic connectivity is key to formulating theories of neural circuit function. Interneurons can be connected by both electrical and chemical synapses, but the organization and interaction of these two complementary microcircuits is unknown. By recording from multiple molecular layer interneurons in the cerebellar cortex, we reveal specific, nonrandom connectivity patterns in both GABAergic chemical and electrical interneuron networks. Both networks contain clustered motifs and show specific overlap between them. Chemical connections exhibit a preference for transitive patterns, such as feedforward triplet motifs. This structured connectivity is supported by a characteristic spatial organization: transitivity of chemical connectivity is directed vertically in the sagittal plane, and electrical synapses appear strictly confined to the sagittal plane. The specific, highly structured connectivity rules suggest that these motifs are essential for the function of the cerebellar network.
date: 2014-02-19
official_url: http://dx.doi.org/10.1016/j.neuron.2013.12.029
vfaculties: VGHCSCI
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Research Support, Non-U.S. Gov't
verified: verified_manual
elements_source: PubMed
elements_id: 932509
doi: 10.1016/j.neuron.2013.12.029
pii: S0896-6273(13)01190-2
lyricists_name: Hausser, Michael
lyricists_name: Roth, Arnd
lyricists_id: MHAUS91
lyricists_id: AROTH52
full_text_status: public
publication: Neuron
volume: 81
number: 4
pagerange: 913 - 929
event_location: United States
issn: 0896-6273
citation:        Rieubland, S;    Roth, A;    Häusser, M;      (2014)    Structured connectivity in cerebellar inhibitory networks.                   Neuron , 81  (4)   913 - 929.    10.1016/j.neuron.2013.12.029 <https://doi.org/10.1016/j.neuron.2013.12.029>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1434836/1/1-s2.0-S0896627313011902-main.pdf