TY  - JOUR
SN  - 0896-6273
UR  - http://dx.doi.org/10.1016/j.neuron.2013.12.029
A1  - Rieubland, S
A1  - Roth, A
A1  - Häusser, M
JF  - Neuron
SP  - 913 
VL  - 81
N1  - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
IS  - 4
ID  - discovery1434836
N2  - Defining the rules governing synaptic connectivity is key to formulating theories of neural circuit function. Interneurons can be connected by both electrical and chemical synapses, but the organization and interaction of these two complementary microcircuits is unknown. By recording from multiple molecular layer interneurons in the cerebellar cortex, we reveal specific, nonrandom connectivity patterns in both GABAergic chemical and electrical interneuron networks. Both networks contain clustered motifs and show specific overlap between them. Chemical connections exhibit a preference for transitive patterns, such as feedforward triplet motifs. This structured connectivity is supported by a characteristic spatial organization: transitivity of chemical connectivity is directed vertically in the sagittal plane, and electrical synapses appear strictly confined to the sagittal plane. The specific, highly structured connectivity rules suggest that these motifs are essential for the function of the cerebellar network.
KW  - Action Potentials
KW  -  Animals
KW  -  Cerebellum
KW  -  Interneurons
KW  -  Nerve Net
KW  -  Neural Pathways
KW  -  Rats
KW  -  Synapses
EP  -  929
AV  - public
Y1  - 2014/02/19/
TI  - Structured connectivity in cerebellar inhibitory networks
ER  -