eprintid: 1434334
rev_number: 52
eprint_status: archive
userid: 608
dir: disk0/01/43/43/34
datestamp: 2014-08-08 08:44:38
lastmod: 2021-10-04 00:54:09
status_changed: 2014-08-08 08:44:38
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Hagen, CK
creators_name: Munro, PRT
creators_name: Endrizzi, M
creators_name: Diemoz, PC
creators_name: Olivo, A
title: Low-dose phase contrast tomography with conventional x-ray sources
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
keywords: Medical x-ray imaging, computed tomography, x-ray imaging, illumination, image reconstruction
note: © 2014 American Association of Physicists in Medicine.. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.
abstract: Purpose: The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented. Methods: Two test objects, a biological sample and a custom-built phantom, were imaged with a laboratory-based EI XPCi setup in tomography mode. Tomographic maps that show the phase shift and attenuating properties of the object were reconstructed, and analyzed in terms of signal-to-noise ratio and quantitative accuracy. Dose measurements using thermoluminescence devices were performed. Results: The obtained images demonstrate that phase based imaging methods can provide superior results compared to attenuation based modalities for weakly attenuating samples also in 3D. Moreover, and, most importantly, they demonstrate the feasibility of low-dose imaging. In addition, the experimental results can be considered quantitative within the constraints imposed by polychromaticity. Conclusions: The results, together with the method's dose efficiency and compatibility with conventional x-ray sources, indicate that tomographic EI XPCi can become an important tool for the routine imaging of biomedical samples.
date: 2014-07
publisher: AAPM/AIP
official_url: http://dx.doi.org/10.1118/1.4884297
vfaculties: VENG
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type: letter
article_type_text: Letter
verified: verified_manual
elements_source: Manually entered
elements_id: 961459
doi: 10.1118/1.4884297
language_elements: EN
lyricists_name: Diemoz, Paul
lyricists_name: Endrizzi, Marco
lyricists_name: Hagen, Charlotte
lyricists_name: Munro, Peter
lyricists_name: Olivo, Alessandro
lyricists_id: PCDIE01
lyricists_id: MENDR57
lyricists_id: CKHAG69
lyricists_id: PRTMU72
lyricists_id: AOLIV86
full_text_status: public
publication: Medical Physics
volume: 41
number: 7
article_number: 070701
place_of_pub: USA
pages: 5
event_location: USA
issn: 0094-2405
citation:        Hagen, CK;    Munro, PRT;    Endrizzi, M;    Diemoz, PC;    Olivo, A;      (2014)    Low-dose phase contrast tomography with conventional x-ray sources.           [Letter].        Medical Physics , 41  (7)    , Article 070701.  10.1118/1.4884297 <https://doi.org/10.1118/1.4884297>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1434334/1/Hagen_MedPhysLett_Published.pdf