eprintid: 1433799
rev_number: 36
eprint_status: archive
userid: 608
dir: disk0/01/43/37/99
datestamp: 2014-07-04 18:54:55
lastmod: 2021-09-20 00:30:59
status_changed: 2014-07-04 18:54:55
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Walsh, J
creators_name: Cram, A
creators_name: Woertz, K
creators_name: Breitkreutz, J
creators_name: Winzenburg, G
creators_name: Turner, R
creators_name: Tuleu, C
creators_name: European Formulation Initiative, 
title: Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Dosage form, Excipient, Formulation, Paediatric, Palatability, Taste masking
note: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: The development of paediatric medicines can be challenging since this is a diverse patient population with specific needs. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Acceptable palatability of oral paediatric medicinal products is of great importance to facilitate patient adherence. This has been recognised by regulatory authorities and so is becoming a key aspect of paediatric pharmaceutical development studies. Many active pharmaceutical ingredients (APIs) have aversive taste characteristics and so it is necessary to utilise taste masking techniques to improve the palatability of paediatric oral formulations. The aim of this review is to provide an overview of different approaches to taste masking APIs in paediatric oral dosage forms, with a focus on the tolerability of excipients used. In addition, where possible, the provision of examples of some marketed products is made.
date: 2014-06-30
official_url: http://dx.doi.org/10.1016/j.addr.2014.02.012
vfaculties: VFLS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 938477
doi: 10.1016/j.addr.2014.02.012
pii: S0169-409X(14)00034-9
language_elements: ENG
lyricists_name: Tuleu, Catherine
lyricists_id: CTULE65
full_text_status: public
publication: Advanced Drug Delivery Reviews
volume: 73
pagerange: 14 - 33
event_location: Netherlands
issn: 0169-409X
citation:        Walsh, J;    Cram, A;    Woertz, K;    Breitkreutz, J;    Winzenburg, G;    Turner, R;    Tuleu, C;           Walsh, J;  Cram, A;  Woertz, K;  Breitkreutz, J;  Winzenburg, G;  Turner, R;  Tuleu, C;  European Formulation Initiative;   - view fewer <#>    (2014)    Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients.                   Advanced Drug Delivery Reviews , 73    14 - 33.    10.1016/j.addr.2014.02.012 <https://doi.org/10.1016/j.addr.2014.02.012>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1433799/1/1-s2.0-S0169409X14000349-main.pdf