eprintid: 1432752
rev_number: 33
eprint_status: archive
userid: 608
dir: disk0/01/43/27/52
datestamp: 2014-06-19 18:59:13
lastmod: 2021-11-04 00:01:18
status_changed: 2016-01-13 16:16:26
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Minton, O
creators_name: Coulton, GR
creators_name: Stone, P
title: Multi-analyte profiling and pathway analysis of plasma for proteins associated with cancer-related fatigue syndrome in disease-free breast cancer patients after primary treatment.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
keywords: Survivorship, Adult, Aged, Aged, 80 and over, Biomarkers, Blood Proteins, Breast Neoplasms, Case-Control Studies, Cytokines, Disease-Free Survival, Fatigue, Female, Humans, Middle Aged, Syndrome
note: This article has been accepted for publication in
BMJ Supportive & Palliative Care following peer
review. The definitive copyedited, typeset version
Minton, O; Coulton, GR; Stone, P; (2014) Multi-analyte profiling and pathway analysis of plasma for proteins associated with cancer-related fatigue syndrome in disease-free breast cancer patients after primary treatment. BMJ Supportive & Palliative Care , 4 (4) pp. 349-356, is available online at: http://dx.doi.org/ 10.1136/bmjspcare-2013-000452.
abstract: CONTEXT: A significant number of women treated for breast cancer develop long-term fatigue afterwards. Previous research has suggested that fatigue may be due to a prolonged inflammatory response. However, there are conflicting results and the exact nature of the disturbance remains unclear. OBJECTIVES: To identify inflammatory markers associated with fatigue. METHODS: We recruited women from a breast cancer follow-up clinic and categorised them on the basis of a diagnostic interview as to whether they met the criteria for cancer-related fatigue syndrome (cases) or not (controls). We took plasma samples from each participant to analyse subsequently using a panel of 88 biological markers. RESULTS: 90 samples were analysed in total (45 cases and 45 controls). A factorial analysis of variance (using age as a fixed factor) demonstrated a number of differences in inflammatory cytokines. There were 28 significantly different analytes in total. Granulocyte colony stimulating factor was the most significantly different analyte (p<0.001). Many of the significant analytes were chemokine ligands found to be linked through an inflammatory pathway promoting T-cell and granulocyte production and activation. CONCLUSIONS: Our results add further weight to the hypothesis that cancer-related fatigue syndrome is associated with an increased pro-inflammatory immune response. Our findings indicate that these cytokine changes could underpin the subjective symptoms, such as perceived muscle weakness and concentration difficulties, experienced by women who feel fatigued after treatment.
date: 2014-12
official_url: http://dx.doi.org/10.1136/bmjspcare-2013-000452
vfaculties: VFBRS
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 952641
doi: 10.1136/bmjspcare-2013-000452
pii: bmjspcare-2013-000452
language_elements: ENG
lyricists_name: Stone, Patrick
lyricists_id: PCSTO82
full_text_status: public
publication: BMJ Supportive & Palliative Care
volume: 4
number: 4
pagerange: 349-356
event_location: England
issn: 2045-4368
citation:        Minton, O;    Coulton, GR;    Stone, P;      (2014)    Multi-analyte profiling and pathway analysis of plasma for proteins associated with cancer-related fatigue syndrome in disease-free breast cancer patients after primary treatment.                   BMJ Supportive & Palliative Care , 4  (4)   pp. 349-356.    10.1136/bmjspcare-2013-000452 <https://doi.org/10.1136/bmjspcare-2013-000452>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1432752/1/Minton_BMJ_updated.pdf