%T A semi-automated technique for labeling and counting of apoptosing retinal cells
%V 15
%A M Bizrah
%A SC Dakin
%A L Guo
%A F Rahman
%A M Parnell
%A E Normando
%A S Nizari
%A B Davis
%A A Younis
%A MF Cordeiro
%N 1
%P 169 -180
%D 2014
%J BMC Bioinformatics
%L discovery1432362
%X Retinal ganglion cell (RGC) loss is one of the earliest and most important cellular changes in glaucoma. The DARC (Detection of Apoptosing Retinal Cells) technology enables in vivo real-time non-invasive imaging of single apoptosing retinal cells in animal models of glaucoma and Alzheimer's disease. To date, apoptosing RGCs imaged using DARC have been counted manually. This is time-consuming, labour-intensive, vulnerable to bias, and has considerable inter- and intra-operator variability
%O © 2014 Bizrah et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, 
unless otherwise stated.