<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1427343> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/title> "The Effect of Renin Angiotensin System Genetic Variants in Acute Pancreatitis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/abstract> "Objectives: We sought association of genetic variants in the renin-angiotensin system (RAS) and vitamin D system with acute pancreatitis (AP) development and severity.\r\n\r\nBackground: The endocrine RAS is involved in circulatory homeostasis through the pressor action of angiotensin II at its AT1 receptor. However, local RAS regulate growth and inflammation in diverse cells and tissues, and their activity may be suppressed by vitamin D. Intrapancreatic angiotensin II generation has been implicated in the development of AP.\r\n\r\nMethods: Five hundred forty-four white patients with AP from 3 countries (United Kingdom, 22; Germany, 136; and The Netherlands 386) and 8487 control subjects (United Kingdom 7833, The Netherlands 717) were genotyped for 8 polymorphisms of the RAS/vitamin D systems, chosen on the basis of likely functionality.\r\n\r\nResults: The angiotensin-converting enzyme I (rather than D) allele was significantly associated with alcohol-related AP when all cohorts were combined (P = 0.03). The renin rs5707 G (rather than A) allele was associated with AP (P = 0.002), infected necrosis (P = 0.025) and mortality (P = 0.046).\r\n\r\nConclusions: The association of 2 RAS polymorphisms with AP suggests the need for further detailed analysis of the role of RAS/vitamin D in the genesis or severity of AP, particularly given the ready potential for pharmacological manipulation of this system using existing marketed agents. However, further replication studies will be required before any such association is considered robust, particularly given the significant heterogeneity of AP causation and clinical course."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/date> "2015-01-01" . <https://discovery.ucl.ac.uk/id/document/633933> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/volume> "261" . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> <http://xmlns.com/foaf/0.1/name> "LIPPINCOTT WILLIAMS & WILKINS"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> . <https://discovery.ucl.ac.uk/id/publication/ext-15281140> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-15281140> <http://xmlns.com/foaf/0.1/name> "Annals of Surgery"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-15281140> . <https://discovery.ucl.ac.uk/id/publication/ext-15281140> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:15281140> . <https://discovery.ucl.ac.uk/id/publication/ext-15281140> <http://purl.org/ontology/bibo/issn> "15281140" . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ad11353143a994b6e68075cc6366adf5> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-ad11353143a994b6e68075cc6366adf5> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8a5a08070391611ef073dc1199de0151> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-8a5a08070391611ef073dc1199de0151> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9107784566bdb07ca91bb5eba7e7c4dc> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-9107784566bdb07ca91bb5eba7e7c4dc> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-12c66a4eb19022880cb8dc05aa053460> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-12c66a4eb19022880cb8dc05aa053460> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-31381943ce78d72733a1f3cc5237987a> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-31381943ce78d72733a1f3cc5237987a> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-896cdbd433164af90663bd2796518f09> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-896cdbd433164af90663bd2796518f09> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6a94f72f265d407ced63d0e2b8bff8b7> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-6a94f72f265d407ced63d0e2b8bff8b7> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-afd0ae3598290566feb1dc06ff57d308> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-afd0ae3598290566feb1dc06ff57d308> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fef93d45dc94ff9cf6876420ba542fb3> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-fef93d45dc94ff9cf6876420ba542fb3> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-aa0570e4149e577c04e52440ccc631d2> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-aa0570e4149e577c04e52440ccc631d2> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e61c61073378c074e8967e4217c0b37f> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e61c61073378c074e8967e4217c0b37f> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fa413aa14f4e7f3d9adfd7ae9c6f3e02> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-fa413aa14f4e7f3d9adfd7ae9c6f3e02> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f7ce6d385e94b7e15906f26993fc3688> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-f7ce6d385e94b7e15906f26993fc3688> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d6b80420caf29f353b2046de711fef7a> . <https://discovery.ucl.ac.uk/id/eprint/1427343> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> . <https://discovery.ucl.ac.uk/id/eprint/1427343#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-d6b80420caf29f353b2046de711fef7a> . <https://discovery.ucl.ac.uk/id/person/ext-6a94f72f265d407ced63d0e2b8bff8b7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6a94f72f265d407ced63d0e2b8bff8b7> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6a94f72f265d407ced63d0e2b8bff8b7> <http://xmlns.com/foaf/0.1/familyName> "Kumari"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6a94f72f265d407ced63d0e2b8bff8b7> <http://xmlns.com/foaf/0.1/name> "M Kumari"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fa413aa14f4e7f3d9adfd7ae9c6f3e02> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-fa413aa14f4e7f3d9adfd7ae9c6f3e02> <http://xmlns.com/foaf/0.1/givenName> "SE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fa413aa14f4e7f3d9adfd7ae9c6f3e02> <http://xmlns.com/foaf/0.1/familyName> "Humphries"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fa413aa14f4e7f3d9adfd7ae9c6f3e02> <http://xmlns.com/foaf/0.1/name> "SE Humphries"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f7ce6d385e94b7e15906f26993fc3688> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f7ce6d385e94b7e15906f26993fc3688> <http://xmlns.com/foaf/0.1/givenName> "SWMO"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f7ce6d385e94b7e15906f26993fc3688> <http://xmlns.com/foaf/0.1/familyName> "Damink"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f7ce6d385e94b7e15906f26993fc3688> <http://xmlns.com/foaf/0.1/name> "SWMO Damink"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-afd0ae3598290566feb1dc06ff57d308> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-afd0ae3598290566feb1dc06ff57d308> <http://xmlns.com/foaf/0.1/givenName> "JA"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-afd0ae3598290566feb1dc06ff57d308> <http://xmlns.com/foaf/0.1/familyName> "Cooper"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-afd0ae3598290566feb1dc06ff57d308> <http://xmlns.com/foaf/0.1/name> "JA Cooper"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9107784566bdb07ca91bb5eba7e7c4dc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9107784566bdb07ca91bb5eba7e7c4dc> <http://xmlns.com/foaf/0.1/givenName> "HC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9107784566bdb07ca91bb5eba7e7c4dc> <http://xmlns.com/foaf/0.1/familyName> "van Santvoort"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9107784566bdb07ca91bb5eba7e7c4dc> <http://xmlns.com/foaf/0.1/name> "HC van Santvoort"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8a5a08070391611ef073dc1199de0151> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8a5a08070391611ef073dc1199de0151> <http://xmlns.com/foaf/0.1/givenName> "RM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8a5a08070391611ef073dc1199de0151> <http://xmlns.com/foaf/0.1/familyName> "Nijmeijer"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8a5a08070391611ef073dc1199de0151> <http://xmlns.com/foaf/0.1/name> "RM Nijmeijer"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e61c61073378c074e8967e4217c0b37f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e61c61073378c074e8967e4217c0b37f> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e61c61073378c074e8967e4217c0b37f> <http://xmlns.com/foaf/0.1/familyName> "Malago"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e61c61073378c074e8967e4217c0b37f> <http://xmlns.com/foaf/0.1/name> "M Malago"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fef93d45dc94ff9cf6876420ba542fb3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-fef93d45dc94ff9cf6876420ba542fb3> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fef93d45dc94ff9cf6876420ba542fb3> <http://xmlns.com/foaf/0.1/familyName> "Acharya"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fef93d45dc94ff9cf6876420ba542fb3> <http://xmlns.com/foaf/0.1/name> "J Acharya"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12c66a4eb19022880cb8dc05aa053460> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-12c66a4eb19022880cb8dc05aa053460> <http://xmlns.com/foaf/0.1/givenName> "MGH"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12c66a4eb19022880cb8dc05aa053460> <http://xmlns.com/foaf/0.1/familyName> "Besselink"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12c66a4eb19022880cb8dc05aa053460> <http://xmlns.com/foaf/0.1/name> "MGH Besselink"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d6b80420caf29f353b2046de711fef7a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d6b80420caf29f353b2046de711fef7a> <http://xmlns.com/foaf/0.1/givenName> "HE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d6b80420caf29f353b2046de711fef7a> <http://xmlns.com/foaf/0.1/familyName> "Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d6b80420caf29f353b2046de711fef7a> <http://xmlns.com/foaf/0.1/name> "HE Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> . 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