<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1425686> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Thesis> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/dc/terms/title> "Acute skeletal muscle wasting in the critically ill"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/ontology/bibo/abstract> "Introduction: Critical illness survivors demonstrate skeletal muscle wasting with associated functional impairment. I prospectively characterised this process, and defined the pathogenic roles of altered protein synthesis and degradation.\r\n\r\nMethods: Critically ill patients (n=63, 59% male, age 54.7±18.0 years, APACHE II score 23.5±6.5) were recruited <24 hours following intensive care admission. Muscle loss trajectory was determined through serial ultrasound measurement of rectus femoris cross-sectional area (RFCSA) and, in a subset, quantification of myofibre area (FibreCSA) and protein/DNA ratio. Histopathological analysis\r\nwas performed. Muscle protein synthesis and breakdown rates were determined and respective signalling pathways examined.\r\n\r\nResults: RFCSA decreased significantly, (-17.7±12.1%, [p<0.001]), underestimating muscle loss determined by FibreCSA (-10.3±10.9% vs.-17.5±30.2%, p=0.31), or protein/DNA ratio (-10.3±10.9% vs. -29.5±41.5%, p=0.03). Fall in RFCSA was greater in multi- than single-organ failure (-21.5±10.5% vs. - 7.2± 9.7%, p <0.0001), even by day 3 (-8.7±16.3% vs. -1.8± 9.6%, p<0.01). Myofibre necrosis occurred in >50% (20/37) of subjects. Protein synthesis was depressed to levels observed in fasted controls (0.035±0.018%/hr vs. 0.039±0.011%/hr, p=0.57), and increased by day 7 (0.076±0.066%/hr, p=0.03)\r\nto levels associated with fed controls (0.065+0.018%/hr, p=0.30,) independent of nutritional load.\r\nProtein breakdown remained elevated throughout (8.5±5.7 to 10.6±5.7mmol phe/min/IBW, p=0.4).Principal component analysis of intracellular signalling supported a programme of increased breakdown (r=-0.83, p=0.005) and depressed synthesis (r=-.69, p=0.041).\r\n\r\nConclusions: Early rapid skeletal muscle wasting occurs in critical illness, is greatest in those with multi-organ failure, and results from suppression of protein synthesis and increases in catabolism. These effects are independent of feeding and are commonly associated with myonecrosis."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/dc/terms/date> "2014-04-28" .
<https://discovery.ucl.ac.uk/id/document/54184> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://xmlns.com/foaf/0.1/name> "UCL (University College London)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/dc/terms/issuer> <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> .
<https://discovery.ucl.ac.uk/id/org/ext-5b57776476c87230ac6228e3e8098d36> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-5b57776476c87230ac6228e3e8098d36> <http://xmlns.com/foaf/0.1/name> "Medicine (Division of), UCL (University College London)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/org/ext-5b57776476c87230ac6228e3e8098d36> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/dc/terms/issuer> <https://discovery.ucl.ac.uk/id/org/ext-5b57776476c87230ac6228e3e8098d36> .
<https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/org/ext-5b57776476c87230ac6228e3e8098d36> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/unpublished> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2a53d249c8696187c433eaa6b0e2dddb> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1425686#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1425686#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-2a53d249c8696187c433eaa6b0e2dddb> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://www.loc.gov/loc.terms/relators/EDT> <https://discovery.ucl.ac.uk/id/person/ext-006ebacb449d2ce4fb912cbad7562e76> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/ontology/bibo/editorList> <https://discovery.ucl.ac.uk/id/eprint/1425686#editors> .
<https://discovery.ucl.ac.uk/id/eprint/1425686#editors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-006ebacb449d2ce4fb912cbad7562e76> .
<https://discovery.ucl.ac.uk/id/person/ext-006ebacb449d2ce4fb912cbad7562e76> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-006ebacb449d2ce4fb912cbad7562e76> <http://xmlns.com/foaf/0.1/givenName> "HE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-006ebacb449d2ce4fb912cbad7562e76> <http://xmlns.com/foaf/0.1/familyName> "Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-006ebacb449d2ce4fb912cbad7562e76> <http://xmlns.com/foaf/0.1/name> "HE Montgomery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2a53d249c8696187c433eaa6b0e2dddb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2a53d249c8696187c433eaa6b0e2dddb> <http://xmlns.com/foaf/0.1/givenName> "ZA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2a53d249c8696187c433eaa6b0e2dddb> <http://xmlns.com/foaf/0.1/familyName> "Puthucheary"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2a53d249c8696187c433eaa6b0e2dddb> <http://xmlns.com/foaf/0.1/name> "ZA Puthucheary"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ThesisEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://www.w3.org/2000/01/rdf-schema#label> "Acute skeletal muscle wasting in the critically ill (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://eprints.org/relation/hasVolatileVersion> <https://discovery.ucl.ac.uk/id/document/95090> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://eprints.org/relation/haspreviewThumbnailVersion> <https://discovery.ucl.ac.uk/id/document/95090> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://eprints.org/relation/hasVersion> <https://discovery.ucl.ac.uk/id/document/95090> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1425686/3/zthesis%20post%20viva.pdf> .
<https://discovery.ucl.ac.uk/id/document/54184> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1425686/3/zthesis%20post%20viva.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/1425686/3/zthesis%20post%20viva.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "zthesis post viva.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/95090> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://www.w3.org/2000/01/rdf-schema#label> "Acute skeletal muscle wasting in the critically ill (Image (PNG))"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1425686/4/preview.png> .
<https://discovery.ucl.ac.uk/id/document/95090> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1425686/4/preview.png> .
<https://discovery.ucl.ac.uk/id/eprint/1425686/4/preview.png> <http://www.w3.org/2000/01/rdf-schema#label> "preview.png"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/121516> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://www.w3.org/2000/01/rdf-schema#label> "Acute skeletal muscle wasting in the critically ill (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/54184> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1425686/5/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/document/121516> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1425686/5/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/eprint/1425686/5/indexcodes.txt> <http://www.w3.org/2000/01/rdf-schema#label> "indexcodes.txt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1425686> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/1425686/> .
<https://discovery.ucl.ac.uk/id/eprint/1425686/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #1425686 \n\nAcute skeletal muscle wasting in the critically ill\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/1425686/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/1425686/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1425686> .