eprintid: 1425474 rev_number: 38 eprint_status: archive userid: 608 dir: disk0/01/42/54/74 datestamp: 2014-03-28 19:37:34 lastmod: 2021-09-19 23:34:23 status_changed: 2015-08-26 11:12:45 type: article metadata_visibility: show item_issues_count: 0 creators_name: Berg, D creators_name: Postuma, RB creators_name: Bloem, B creators_name: Chan, P creators_name: Dubois, B creators_name: Gasser, T creators_name: Goetz, CG creators_name: Halliday, GM creators_name: Hardy, J creators_name: Lang, AE creators_name: Litvan, I creators_name: Marek, K creators_name: Obeso, J creators_name: Oertel, W creators_name: Olanow, CW creators_name: Poewe, W creators_name: Stern, M creators_name: Deuschl, G title: Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: MDS diagnostic criteria, disease heterogeneity, gold standard, nonmotor prodrome, redefinition of PD, subtypes, Advisory Committees, Diagnostic and Statistical Manual of Mental Disorders, Humans, Neuropsychological Tests, Parkinson Disease note: © 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: With advances in knowledge disease, boundaries may change. Occasionally, these changes are of such a magnitude that they require redefinition of the disease. In recognition of the profound changes in our understanding of Parkinson's disease (PD), the International Parkinson and Movement Disorders Society (MDS) commissioned a task force to consider a redefinition of PD. This review is a discussion article, intended as the introductory statement of the task force. Several critical issues were identified that challenge current PD definitions. First, new findings challenge the central role of the classical pathologic criteria as the arbiter of diagnosis, notably genetic cases without synuclein deposition, the high prevalence of incidental Lewy body (LB) deposition, and the nonmotor prodrome of PD. It remains unclear, however, whether these challenges merit a change in the pathologic gold standard, especially considering the limitations of alternate gold standards. Second, the increasing recognition of dementia in PD challenges the distinction between diffuse LB disease and PD. Consideration might be given to removing dementia as an exclusion criterion for PD diagnosis. Third, there is increasing recognition of disease heterogeneity, suggesting that PD subtypes should be formally identified; however, current subtype classifications may not be sufficiently robust to warrant formal delineation. Fourth, the recognition of a nonmotor prodrome of PD requires that new diagnostic criteria for early-stage and prodromal PD should be created; here, essential features of these criteria are proposed. Finally, there is a need to create new MDS diagnostic criteria that take these changes in disease definition into consideration. date: 2014-04 date_type: published official_url: http:://dx.doi.org/10.1002/mds.25844 vfaculties: VFBRS oa_status: green full_text_type: pub pmcid: PMC4204150 primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_source: PubMed elements_id: 939250 doi: 10.1002/mds.25844 language_elements: eng lyricists_name: Hardy, John lyricists_name: Smalley, June lyricists_id: JHARD28 lyricists_id: JASMA87 actors_name: Hardy, John actors_name: Donadello, Ivan actors_id: JHARD28 actors_id: IDONA64 actors_role: owner actors_role: impersonator full_text_status: public publication: Mov Disord volume: 29 number: 4 pagerange: 454-462 event_location: United States issn: 1531-8257 citation: Berg, D; Postuma, RB; Bloem, B; Chan, P; Dubois, B; Gasser, T; Goetz, CG; ... Deuschl, G; + view all <#> Berg, D; Postuma, RB; Bloem, B; Chan, P; Dubois, B; Gasser, T; Goetz, CG; Halliday, GM; Hardy, J; Lang, AE; Litvan, I; Marek, K; Obeso, J; Oertel, W; Olanow, CW; Poewe, W; Stern, M; Deuschl, G; - view fewer <#> (2014) Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Mov Disord , 29 (4) pp. 454-462. 10.1002/mds.25844 <https://doi.org/10.1002/mds.25844>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1425474/1/Time%20to%20redefine%20PD%3F%20Introductory%20statement%20of%20the%20MDS%20Task%20Force%20on%20the%20definition%20of%20Parkinson%27s%20disease..pdf