eprintid: 1424808 rev_number: 36 eprint_status: archive userid: 608 dir: disk0/01/42/48/08 datestamp: 2014-03-25 22:30:30 lastmod: 2021-12-27 01:31:33 status_changed: 2017-05-26 13:40:35 type: article metadata_visibility: show item_issues_count: 0 creators_name: Ghasemzadeh, N creators_name: Patel, RS creators_name: Eapen, DJ creators_name: Veledar, E creators_name: Al Kassem, H creators_name: Manocha, P creators_name: Khayata, M creators_name: Zafari, AM creators_name: Sperling, L creators_name: Jones, DP creators_name: Quyyumi, AA title: Oxidative Stress Is Associated With Increased Pulmonary Artery Systolic Pressure in Humans ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA3 keywords: Science & Technology, Life Sciences & Biomedicine, Peripheral Vascular Disease, Cardiovascular System & Cardiology, PERIPHERAL VASCULAR DISEASE, cystine, hypertension, pulmonary, oxidative stress, TRANSGENIC (MREN2)27 RAT, HUMAN PLASMA, DOPPLER-ECHOCARDIOGRAPHY, ANTIOXIDANT THERAPY, LIPID-PEROXIDATION, METABOLIC SYNDROME, HEALTHY-ADULTS, REDOX STATE, HYPERTENSION, SUPEROXIDE note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association in humans is unknown. We investigated the relationship between pulmonary artery systolic pressure measured by echocardiography and plasma aminothiol oxidative stress markers, with the hypothesis that oxidative stress will be higher in those with pulmonary hypertension. A group of 347 patients aged 65±12 years from the Emory Cardiovascular Biobank underwent echocardiographic assessment of left ventricular ejection fraction and pulmonary artery systolic pressure. Plasma aminothiols, cysteine, its oxidized form, cystine, glutathione, and its oxidized disulphide were measured and the redox potentials (Eh) of cysteine/cystine and glutathione/oxidized glutathione couples were calculated. Non-normally distributed variables were log transformed (Ln). Univariate predictors of pulmonary artery systolic pressure included age (P<0.001), sex (P=0.002), mitral regurgitation (P<0.001), left ventricular ejection fraction (P<0.001), left atrial size (P<0.001), diabetes mellitus (P=0.03), plasma Ln cystine (β=9.53; P<0.001), Ln glutathione (β=−5.4; P=0.002), and Eh glutathione (β=0.21; P=0.001). A multivariate linear regression model adjusting for all confounding variables demonstrated that Ln cystine (β=6.56; P=0.007), mitral regurgitation (β=4.52; P<0.001), statin use (β=−3.39; P=0.03), left ventricular ejection fraction (β=−0.26; P=0.003), and age (β=0.17; P=0.003) were independent predictors of pulmonary artery systolic pressure. For each 1% increase in plasma cystine, pulmonary artery systolic pressure increased by 16%. This association persisted in the subgroup with preserved left ventricular ejection fraction (≥50%) and no significant mitral regurgitation. Whether treatment of oxidative stress will improve pulmonary hypertension requires further study. date: 2014-06-01 date_type: published publisher: LIPPINCOTT WILLIAMS & WILKINS official_url: http://doi.org/10.1161/HYPERTENSIONAHA.113.02360 vfaculties: VFPHS oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_source: PubMed elements_id: 938335 doi: 10.1161/HYPERTENSIONAHA.113.02360 language_elements: English lyricists_name: Patel, Riyaz lyricists_id: RSPAT27 actors_name: Patel, Riyaz actors_name: Laslett, David actors_id: RSPAT27 actors_id: DLASL34 actors_role: owner actors_role: impersonator full_text_status: public publication: Hypertension volume: 63 number: 6 pagerange: 1270-1275 pages: 6 issn: 1524-4563 citation: Ghasemzadeh, N; Patel, RS; Eapen, DJ; Veledar, E; Al Kassem, H; Manocha, P; Khayata, M; ... Quyyumi, AA; + view all <#> Ghasemzadeh, N; Patel, RS; Eapen, DJ; Veledar, E; Al Kassem, H; Manocha, P; Khayata, M; Zafari, AM; Sperling, L; Jones, DP; Quyyumi, AA; - view fewer <#> (2014) Oxidative Stress Is Associated With Increased Pulmonary Artery Systolic Pressure in Humans. Hypertension , 63 (6) pp. 1270-1275. 10.1161/HYPERTENSIONAHA.113.02360 <https://doi.org/10.1161/HYPERTENSIONAHA.113.02360>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1424808/1/Patel_nihms567602.pdf