eprintid: 1424808
rev_number: 36
eprint_status: archive
userid: 608
dir: disk0/01/42/48/08
datestamp: 2014-03-25 22:30:30
lastmod: 2021-12-27 01:31:33
status_changed: 2017-05-26 13:40:35
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Ghasemzadeh, N
creators_name: Patel, RS
creators_name: Eapen, DJ
creators_name: Veledar, E
creators_name: Al Kassem, H
creators_name: Manocha, P
creators_name: Khayata, M
creators_name: Zafari, AM
creators_name: Sperling, L
creators_name: Jones, DP
creators_name: Quyyumi, AA
title: Oxidative Stress Is Associated With Increased Pulmonary Artery Systolic Pressure in Humans
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA3
keywords: Science & Technology, Life Sciences & Biomedicine, Peripheral Vascular Disease, Cardiovascular System & Cardiology, PERIPHERAL VASCULAR DISEASE, cystine, hypertension, pulmonary, oxidative stress, TRANSGENIC (MREN2)27 RAT, HUMAN PLASMA, DOPPLER-ECHOCARDIOGRAPHY, ANTIOXIDANT THERAPY, LIPID-PEROXIDATION, METABOLIC SYNDROME, HEALTHY-ADULTS, REDOX STATE, HYPERTENSION, SUPEROXIDE
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association in humans is unknown. We investigated the relationship between pulmonary artery systolic pressure measured by echocardiography and plasma aminothiol oxidative stress markers, with the hypothesis that oxidative stress will be higher in those with pulmonary hypertension. A group of 347 patients aged 65±12 years from the Emory Cardiovascular Biobank underwent echocardiographic assessment of left ventricular ejection fraction and pulmonary artery systolic pressure. Plasma aminothiols, cysteine, its oxidized form, cystine, glutathione, and its oxidized disulphide were measured and the redox potentials (Eh) of cysteine/cystine and glutathione/oxidized glutathione couples were calculated. Non-normally distributed variables were log transformed (Ln). Univariate predictors of pulmonary artery systolic pressure included age (P<0.001), sex (P=0.002), mitral regurgitation (P<0.001), left ventricular ejection fraction (P<0.001), left atrial size (P<0.001), diabetes mellitus (P=0.03), plasma Ln cystine (β=9.53; P<0.001), Ln glutathione (β=−5.4; P=0.002), and Eh glutathione (β=0.21; P=0.001). A multivariate linear regression model adjusting for all confounding variables demonstrated that Ln cystine (β=6.56; P=0.007), mitral regurgitation (β=4.52; P<0.001), statin use (β=−3.39; P=0.03), left ventricular ejection fraction (β=−0.26; P=0.003), and age (β=0.17; P=0.003) were independent predictors of pulmonary artery systolic pressure. For each 1% increase in plasma cystine, pulmonary artery systolic pressure increased by 16%. This association persisted in the subgroup with preserved left ventricular ejection fraction (≥50%) and no significant mitral regurgitation. Whether treatment of oxidative stress will improve pulmonary hypertension requires further study.
date: 2014-06-01
date_type: published
publisher: LIPPINCOTT WILLIAMS & WILKINS
official_url: http://doi.org/10.1161/HYPERTENSIONAHA.113.02360
vfaculties: VFPHS
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_source: PubMed
elements_id: 938335
doi: 10.1161/HYPERTENSIONAHA.113.02360
language_elements: English
lyricists_name: Patel, Riyaz
lyricists_id: RSPAT27
actors_name: Patel, Riyaz
actors_name: Laslett, David
actors_id: RSPAT27
actors_id: DLASL34
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Hypertension
volume: 63
number: 6
pagerange: 1270-1275
pages: 6
issn: 1524-4563
citation:        Ghasemzadeh, N;    Patel, RS;    Eapen, DJ;    Veledar, E;    Al Kassem, H;    Manocha, P;    Khayata, M;                 ... Quyyumi, AA; + view all <#>        Ghasemzadeh, N;  Patel, RS;  Eapen, DJ;  Veledar, E;  Al Kassem, H;  Manocha, P;  Khayata, M;  Zafari, AM;  Sperling, L;  Jones, DP;  Quyyumi, AA;   - view fewer <#>    (2014)    Oxidative Stress Is Associated With Increased Pulmonary Artery Systolic Pressure in Humans.                   Hypertension , 63  (6)   pp. 1270-1275.    10.1161/HYPERTENSIONAHA.113.02360 <https://doi.org/10.1161/HYPERTENSIONAHA.113.02360>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1424808/1/Patel_nihms567602.pdf