eprintid: 1422521 rev_number: 33 eprint_status: archive userid: 608 dir: disk0/01/42/25/21 datestamp: 2014-03-22 00:38:38 lastmod: 2021-11-30 23:07:07 status_changed: 2014-03-22 00:38:38 type: article metadata_visibility: show item_issues_count: 0 creators_name: Williams, B creators_name: Cockcroft, JR creators_name: Kario, K creators_name: Zappe, DH creators_name: Cardenas, P creators_name: Hester, A creators_name: Brunel, P creators_name: Zhang, J title: Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study. ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA3 note: © 2014 by the BMJ Publishing Group Ltd. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ abstract: Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness. LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), is being developed to treat hypertension and heart failure. The Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study will assess the efficacy of LCZ696 versus olmesartan on aortic stiffness and central aortic haemodynamics. date: 2014-02-04 official_url: http://dx.doi.org/10.1136/bmjopen-2013-004254 vfaculties: VFPHS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_source: PubMed elements_id: 926376 doi: 10.1136/bmjopen-2013-004254 pii: bmjopen-2013-004254 lyricists_name: Williams, Bryan lyricists_id: BWILL10 full_text_status: public publication: BMJ Open volume: 4 number: 2 article_number: e004254 pagerange: - event_location: England citation: Williams, B; Cockcroft, JR; Kario, K; Zappe, DH; Cardenas, P; Hester, A; Brunel, P; Williams, B; Cockcroft, JR; Kario, K; Zappe, DH; Cardenas, P; Hester, A; Brunel, P; Zhang, J; - view fewer <#> (2014) Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study. BMJ Open , 4 (2) , Article e004254. 10.1136/bmjopen-2013-004254 <https://doi.org/10.1136/bmjopen-2013-004254>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1422521/1/e004254.full.pdf