eprintid: 1422521
rev_number: 33
eprint_status: archive
userid: 608
dir: disk0/01/42/25/21
datestamp: 2014-03-22 00:38:38
lastmod: 2021-11-30 23:07:07
status_changed: 2014-03-22 00:38:38
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Williams, B
creators_name: Cockcroft, JR
creators_name: Kario, K
creators_name: Zappe, DH
creators_name: Cardenas, P
creators_name: Hester, A
creators_name: Brunel, P
creators_name: Zhang, J
title: Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study.
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA3
note: © 2014 by the BMJ Publishing Group Ltd. All rights reserved.
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
abstract: Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness. LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), is being developed to treat hypertension and heart failure. The Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study will assess the efficacy of LCZ696 versus olmesartan on aortic stiffness and central aortic haemodynamics.
date: 2014-02-04
official_url: http://dx.doi.org/10.1136/bmjopen-2013-004254
vfaculties: VFPHS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 926376
doi: 10.1136/bmjopen-2013-004254
pii: bmjopen-2013-004254
lyricists_name: Williams, Bryan
lyricists_id: BWILL10
full_text_status: public
publication: BMJ Open
volume: 4
number: 2
article_number: e004254
pagerange: -
event_location: England
citation:        Williams, B;    Cockcroft, JR;    Kario, K;    Zappe, DH;    Cardenas, P;    Hester, A;    Brunel, P;           Williams, B;  Cockcroft, JR;  Kario, K;  Zappe, DH;  Cardenas, P;  Hester, A;  Brunel, P;  Zhang, J;   - view fewer <#>    (2014)    Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study.                   BMJ Open , 4  (2)    , Article e004254.  10.1136/bmjopen-2013-004254 <https://doi.org/10.1136/bmjopen-2013-004254>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1422521/1/e004254.full.pdf