eprintid: 1421229
rev_number: 35
eprint_status: archive
userid: 608
dir: disk0/01/42/12/29
datestamp: 2014-03-17 19:46:37
lastmod: 2021-12-13 02:07:34
status_changed: 2014-03-17 19:46:37
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Wells, JC
creators_name: Cole, TJ
title: Height, adiposity and hormonal cardiovascular risk markers in childhood: how to partition the associations?
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G25
keywords: BMI; cardiovascular risk; size adjustment; adiposity; leptin; insulin resistance
note: © 2014 Macmillan Publishers Limited All rights reserved. 
This work is licensed under a Creative Commons Attribution 3.0
Unported License. To view a copy of this license, visit http://
creativecommons.org/licenses/by/3.0/
abstract: Objective:Obesity is associated with rapid growth during childhood. There is uncertainty over how to adjust for body size, when using adiposity as a proxy for cardiovascular risk. We studied associations of height, body composition (by dual-energy X-ray absorptiometry) and cardiovascular risk markers (insulin resistance (IR), leptin) in children.Methods:Using partial correlations in 172 children aged 7-12 years, we investigated associations of (a) fat mass with IR or leptin, adjusting for height, or lean mass, and (b) height or lean mass with IR or leptin, adjusting for fat mass. Analyses were conducted both cross-sectionally at each age, and for changes between 7 and 12 years.Results:Height, fat mass, lean mass, IR and leptin were all inter-correlated at all ages. Whilst fat mass was strongly associated with IR and leptin, height was independently negatively associated with leptin (whole sample, adjusting for age: boys r=-0.12, girls r=-0.13; P<0.001). Independent of adiposity, height was also associated with insulin IR (whole sample, adjusting for age: boys r=0.11, girls r=0.20; P<0.001). When analyzed by year of age, these associations tended to remain significant at older ages. Change in height from 7-12 years was also associated with change in IR (boys: r=0.18, P<0.05; girls: r=0.34, P<0.01), independently of change in adiposity, with similar findings for lean mass.Conclusions:During childhood, markers of cardiovascular risk have a complex profile, responding to growth as well as fat accumulation. Taller and faster-growing children have elevated risk markers, independently of their adiposity. These findings have implications for the interpretation of pediatric indices of adiposity that aim to adjust for body size. Adiposity indices that perform best at summarizing metabolic risk may not be those that perform best at understanding the developmental aetiology of risk.International Journal of Obesity accepted article preview online, 10 February 2014; doi:10.1038/ijo.2014.24.
date: 2014-07
official_url: http://dx.doi.org/10.1038/ijo.2014.24
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: JOURNAL ARTICLE
verified: verified_manual
elements_source: PubMed
elements_id: 929062
doi: 10.1038/ijo.2014.24
pii: ijo201424
language_elements: ENG
lyricists_name: Cole, Timothy
lyricists_name: Wells, Jonathan
lyricists_id: TCOLE39
lyricists_id: JWELL04
full_text_status: public
publication: Int J Obes (Lond)
volume: 38
number: 7
pagerange: 930-935
citation:        Wells, JC;    Cole, TJ;      (2014)    Height, adiposity and hormonal cardiovascular risk markers in childhood: how to partition the associations?                   Int J Obes (Lond) , 38  (7)   pp. 930-935.    10.1038/ijo.2014.24 <https://doi.org/10.1038/ijo.2014.24>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1421229/1/ijo201424a.pdf