TY  - JOUR
KW  - Cardiovascular diseases
KW  -  exosomes
KW  -  heart
N2  - Exosomes are nanosized lipid vesicles released from cells. They are capable of transferring proteins, mRNA, and miRNA between cells and, therefore, represent a potential means of intercellular communication. Exosomes can be proangiogenic and may have cardioprotective properties. In contrast, their larger cousins, microvesicles, seem to have generally detrimental effects that are prothrombotic and proinflammatory. Exosomes are released from multivesicular bodies via an exocytic pathway and have the potential for cell-specific targeting. This normal process is hijacked during various pathological conditions, such as cancer, viral infection, and amyloidopathies. We assess the evidence for a role of exosomes and microvesicles in normal cardiovascular physiology, as well as during cardiovascular disease. In addition to offering a potential source of cardiovascular biomarkers, exosomes may offer a nonimmunogenic means of manipulating the heart.
ID  - discovery1420537
AV  - public
Y1  - 2014/01/17/
EP  -  332
TI  - Exosomes: nanoparticles involved in cardioprotection?
A1  - Yellon, DM
A1  - Davidson, SM
JF  - Circulation Research
UR  - http://dx.doi.org/10.1161/CIRCRESAHA.113.300636
SN  -  0009-7330
IS  - 2
N1  - © 2014 American Heart Association
VL  - 114
SP  - 325 
ER  -