<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1417114> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/title> "CYP2D6 Genotype and Tamoxifen Response for Breast Cancer: A Systematic Review and Meta-Analysis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/abstract> "Objective\r\n\r\nTo evaluate evidence on the association between CYP2D6 genotype and tamoxifen response through.\r\nDesign\r\n\r\nSystematic review and meta-analysis of prospective, cross-sectional and case-control studies published to 2012. For each study, relative risks and 95% confidence intervals were extracted and pooled with a fixed and random effects model. Heterogeneity, publication bias, subgroup, and meta-regression analyses were performed.\r\nData Sources\r\n\r\nPubMed (inception-2012) and EMBASE (inception-2012).\r\nEligibility Criteria for Selecting Studies\r\n\r\nCriteria for inclusion were studies reporting breast cancer outcomes in patients treated with tamoxifen and genotyped for polymorphisms in the CYP2D6 gene.\r\nResults\r\n\r\nTwenty-five studies of 13,629 individuals were identified, of which 22 investigated the association of CYP2D6 genotype with outcomes in breast cancer women all receiving tamoxifen treatment (“treatment-only†design). Three randomized trials evaluated the effect of CYP2D6 genotype on tamoxifen response (“effect modification†design). In analysis of treatment-only studies, the relative risk (RR) of all-cause mortality (>307 events in 4,936 patients) for carriers of a CYP2D6 reduced function allele was 1.11 (95% confidence interval (CI): 0.94 to 1.31) compared to individuals with normal/increased function CYP2D6 alleles. When we investigated a composite outcome including all-cause mortality and surrogate endpoints for overall survival (>307 events in 6,721 patients), carriers of a CYP2D6 reduced function allele had a RR of 1.27 (95% CI: 1.11 to 1.45). From two randomized trials that permitted effect-modification analysis, one had only 154 patients and showed evidence of effect modification of tamoxifen by CYP2D6 genotype for distant recurrence but was directionally opposite to that predicted, whereas a larger trial of 2,537 patients failed to show evidence of effect modification for breast cancer-free interval (P values for interaction 0.02 and 0.44, respectively).\r\nConclusions\r\n\r\nBased on these findings, there is insufficient evidence to recommend CYP2D6 genotyping to guide tamoxifen treatment."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/date> "2013-10-02" . <https://discovery.ucl.ac.uk/id/document/59949> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/volume> "8" . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/issue> "10" . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://xmlns.com/foaf/0.1/name> "PLoS One"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-19326203> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:19326203> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://purl.org/ontology/bibo/issn> "19326203" . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bc508b540f6bf8b7393772bd8a8c8762> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> . <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-bc508b540f6bf8b7393772bd8a8c8762> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2a68a478694d0ccea622feec955d77e1> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> . <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-2a68a478694d0ccea622feec955d77e1> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1511a94fe3cfd2e5bc6c12e75e143b3c> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> . <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-1511a94fe3cfd2e5bc6c12e75e143b3c> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e9e836eb2132f51569fdff852afabe62> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> . <https://discovery.ucl.ac.uk/id/eprint/1417114#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e9e836eb2132f51569fdff852afabe62> . <https://discovery.ucl.ac.uk/id/person/ext-2a68a478694d0ccea622feec955d77e1> 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<http://xmlns.com/foaf/0.1/familyName> "Lum"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc508b540f6bf8b7393772bd8a8c8762> <http://xmlns.com/foaf/0.1/name> "DW Lum"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e9e836eb2132f51569fdff852afabe62> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e9e836eb2132f51569fdff852afabe62> <http://xmlns.com/foaf/0.1/givenName> "MV"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e9e836eb2132f51569fdff852afabe62> <http://xmlns.com/foaf/0.1/familyName> "Holmes"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e9e836eb2132f51569fdff852afabe62> <http://xmlns.com/foaf/0.1/name> "MV Holmes"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1511a94fe3cfd2e5bc6c12e75e143b3c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1511a94fe3cfd2e5bc6c12e75e143b3c> <http://xmlns.com/foaf/0.1/givenName> "AD"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1511a94fe3cfd2e5bc6c12e75e143b3c> <http://xmlns.com/foaf/0.1/familyName> "Hingorani"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1511a94fe3cfd2e5bc6c12e75e143b3c> <http://xmlns.com/foaf/0.1/name> "AD Hingorani"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/1417114> <http://purl.org/dc/terms/isPartOf> 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