TY - JOUR IS - 7 N1 - PMCID: PMC3409138 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license. Authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles in PLOS journals, so long as the original authors and source are cited. SP - ? VL - 9 JF - PLoS Med A1 - Schlackow, I A1 - Walker, AS A1 - Dingle, K A1 - Griffiths, D A1 - Oakley, S A1 - Finney, J A1 - Vaughan, A A1 - Gill, MJ A1 - Crook, DW A1 - Peto, TE A1 - Wyllie, DH UR - http://dx.doi.org/10.1371/journal.pmed.1001279 SN - 1549-1277 TI - Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile Y1 - 2012/07// AV - public EP - ? KW - Aged KW - Aged KW - 80 and over KW - Clostridium Infections KW - Clostridium difficile KW - Computer Simulation KW - Demography KW - Female KW - Great Britain KW - Humans KW - Incidence KW - Laboratories KW - Hospital KW - Male KW - Models KW - Biological KW - Neutrophils KW - Population Surveillance KW - Registries KW - Regression Analysis KW - Reproducibility of Results KW - Retrospective Studies KW - Severity of Illness Index KW - Virulence N2 - Changing clinical impact, as virulent clones replace less virulent ones, is a feature of many pathogenic bacterial species and can be difficult to detect. Consequently, innovative techniques monitoring infection severity are of potential clinical value. ID - discovery1417043 ER -