<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1416406> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/title> "Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/abstract> "Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death. In rodents, inhibition of this pathway causes selective dopaminergic cell death leading to motor deficits resembling parkinsonism. Using postmortem human brain tissue, we characterized glucose metabolism via the PPP in sporadic Parkinson's disease (PD), Alzheimer's disease (AD), and controls. AD brains showed increased nicotinamide adenine dinucleotide phosphate (NADPH) production in areas affected by disease. In PD however, increased NADPH production was only seen in the affected areas of late-stage cases. Quantifying PPP NADPH-producing enzymes glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase by enzyme-linked immunosorbent assay, showed a reduction in the putamen of early-stage PD and interestingly in the cerebellum of early and late-stage PD. Importantly, there was no decrease in enzyme levels in the cortex, putamen, or cerebellum of AD. Our results suggest that down-regulation of PPP enzymes and a failure to increase antioxidant reserve is an early event in the pathogenesis of sporadic PD."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/date> "2014-11" .
<https://discovery.ucl.ac.uk/id/document/59486> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/volume> "35" .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/issue> "5" .
<https://discovery.ucl.ac.uk/id/publication/ext-f37ba8db062ba8bf0513edb97cd2e2ec> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-f37ba8db062ba8bf0513edb97cd2e2ec> <http://xmlns.com/foaf/0.1/name> "Neurobiol Aging"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-f37ba8db062ba8bf0513edb97cd2e2ec> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8df67d93e35a24a034a39a9445c2e7d2> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-8df67d93e35a24a034a39a9445c2e7d2> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5415d69749fe103a91c15fc72159d5a4> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-5415d69749fe103a91c15fc72159d5a4> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-809b7fd51c2eb4a81502b885f05c65a4> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-809b7fd51c2eb4a81502b885f05c65a4> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-937766d925ac508bad6f50fa0632c509> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-937766d925ac508bad6f50fa0632c509> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-590883abb0e84c1f32bf5c468668de3b> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-590883abb0e84c1f32bf5c468668de3b> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8cb7dbca2cb0d43db07cce7b745f4992> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-8cb7dbca2cb0d43db07cce7b745f4992> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-72f832c05f31782e06fb2454fe1761c4> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-72f832c05f31782e06fb2454fe1761c4> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9664b962fb2e0ef6624ef4f3e1260200> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-9664b962fb2e0ef6624ef4f3e1260200> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a7c0140e7fc31657c7a1e3baf29f845a> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a7c0140e7fc31657c7a1e3baf29f845a> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8311e3bb34e2cdb37cbefe3e7cf1c0dc> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-8311e3bb34e2cdb37cbefe3e7cf1c0dc> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-66eaf79b5595c74946f97e69bb95137b> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-66eaf79b5595c74946f97e69bb95137b> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-af8d754ba6be8e44a6d0016d8299e2ca> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1416406#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1416406#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-af8d754ba6be8e44a6d0016d8299e2ca> .
<https://discovery.ucl.ac.uk/id/person/ext-66eaf79b5595c74946f97e69bb95137b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-66eaf79b5595c74946f97e69bb95137b> <http://xmlns.com/foaf/0.1/givenName> "SJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-66eaf79b5595c74946f97e69bb95137b> <http://xmlns.com/foaf/0.1/familyName> "Heales"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-66eaf79b5595c74946f97e69bb95137b> <http://xmlns.com/foaf/0.1/name> "SJ Heales"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5415d69749fe103a91c15fc72159d5a4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5415d69749fe103a91c15fc72159d5a4> <http://xmlns.com/foaf/0.1/givenName> "GF"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5415d69749fe103a91c15fc72159d5a4> <http://xmlns.com/foaf/0.1/familyName> "Allen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5415d69749fe103a91c15fc72159d5a4> <http://xmlns.com/foaf/0.1/name> "GF Allen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-590883abb0e84c1f32bf5c468668de3b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-590883abb0e84c1f32bf5c468668de3b> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-590883abb0e84c1f32bf5c468668de3b> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-590883abb0e84c1f32bf5c468668de3b> <http://xmlns.com/foaf/0.1/name> "A Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-937766d925ac508bad6f50fa0632c509> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-937766d925ac508bad6f50fa0632c509> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-937766d925ac508bad6f50fa0632c509> <http://xmlns.com/foaf/0.1/familyName> "Ling"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-937766d925ac508bad6f50fa0632c509> <http://xmlns.com/foaf/0.1/name> "H Ling"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9664b962fb2e0ef6624ef4f3e1260200> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9664b962fb2e0ef6624ef4f3e1260200> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9664b962fb2e0ef6624ef4f3e1260200> <http://xmlns.com/foaf/0.1/familyName> "Pope"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9664b962fb2e0ef6624ef4f3e1260200> <http://xmlns.com/foaf/0.1/name> "S Pope"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8311e3bb34e2cdb37cbefe3e7cf1c0dc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8311e3bb34e2cdb37cbefe3e7cf1c0dc> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8311e3bb34e2cdb37cbefe3e7cf1c0dc> <http://xmlns.com/foaf/0.1/familyName> "Lees"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8311e3bb34e2cdb37cbefe3e7cf1c0dc> <http://xmlns.com/foaf/0.1/name> "A Lees"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8cb7dbca2cb0d43db07cce7b745f4992> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8cb7dbca2cb0d43db07cce7b745f4992> <http://xmlns.com/foaf/0.1/givenName> "KE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8cb7dbca2cb0d43db07cce7b745f4992> <http://xmlns.com/foaf/0.1/familyName> "Duberley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8cb7dbca2cb0d43db07cce7b745f4992> <http://xmlns.com/foaf/0.1/name> "KE Duberley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a7c0140e7fc31657c7a1e3baf29f845a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a7c0140e7fc31657c7a1e3baf29f845a> <http://xmlns.com/foaf/0.1/givenName> "JL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a7c0140e7fc31657c7a1e3baf29f845a> <http://xmlns.com/foaf/0.1/familyName> "Holton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a7c0140e7fc31657c7a1e3baf29f845a> <http://xmlns.com/foaf/0.1/name> "JL Holton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-809b7fd51c2eb4a81502b885f05c65a4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-809b7fd51c2eb4a81502b885f05c65a4> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-809b7fd51c2eb4a81502b885f05c65a4> <http://xmlns.com/foaf/0.1/familyName> "Mamais"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-809b7fd51c2eb4a81502b885f05c65a4> <http://xmlns.com/foaf/0.1/name> "A Mamais"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-72f832c05f31782e06fb2454fe1761c4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-72f832c05f31782e06fb2454fe1761c4> <http://xmlns.com/foaf/0.1/givenName> "IP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-72f832c05f31782e06fb2454fe1761c4> <http://xmlns.com/foaf/0.1/familyName> "Hargreaves"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-72f832c05f31782e06fb2454fe1761c4> <http://xmlns.com/foaf/0.1/name> "IP Hargreaves"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-af8d754ba6be8e44a6d0016d8299e2ca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-af8d754ba6be8e44a6d0016d8299e2ca> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-af8d754ba6be8e44a6d0016d8299e2ca> <http://xmlns.com/foaf/0.1/familyName> "Bandopadhyay"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-af8d754ba6be8e44a6d0016d8299e2ca> <http://xmlns.com/foaf/0.1/name> "R Bandopadhyay"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8df67d93e35a24a034a39a9445c2e7d2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8df67d93e35a24a034a39a9445c2e7d2> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8df67d93e35a24a034a39a9445c2e7d2> <http://xmlns.com/foaf/0.1/familyName> "Dunn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8df67d93e35a24a034a39a9445c2e7d2> <http://xmlns.com/foaf/0.1/name> "L Dunn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/1416406> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/59486> .
<https://discovery.ucl.ac.uk/id/document/59486> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/59486> <http://www.w3.org/2000/01/rdf-schema#label> "Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease. (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> .
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