TY  - JOUR
UR  - http://dx.doi.org/10.1063/1.4821277
KW  - x-ray imaging
KW  -  phase contrast imaging
KW  -  dark field imaging
KW  -  microbubbles
TI  - Quantification of microbubble concentration through x-ray phase contrast imaging
SN  - 0003-6951
N1  - © 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters / Volume 103 / Issue 11 / INTERDISCIPLINARY AND GENERAL PHYSICS and may be found at http://apl.aip.org/resource/1/applab/v103/i11/p114105_s1
ID  - discovery1405990
AV  - public
JF  - Applied Physics Letters
EP  - 4
N2  - The use of microbubbles as a contrast agent for x-ray phase contrast imaging could both transform x-ray imaging into a ?functional? modality and enable much needed monitoring of targeted drug delivery. To realize these benefits, it is essential to be able to quantify bubble concentration in a given tissue volume. We developed and validated a model that enables this to be achieved not only for phase-retrieved images obtained by processing multiple frames but also on ?single-shot? images, a likely necessity in in-vivo implementations. Our experimental validation was based on analyzer-based imaging, but extension to other phase-based modalities is straightforward.
CY  - US
VL  - 103
IS  - 11
A1  - Millard, TP
A1  - Endrizzi, M
A1  - Rigon, L
A1  - Arfelli, F
A1  - Menk, RH
A1  - Owen, J
A1  - Stride, E
A1  - Olivo, A
PB  - AIP
Y1  - 2013/09/09/
ER  -