eprintid: 1405322 rev_number: 36 eprint_status: archive userid: 608 dir: disk0/01/40/53/22 datestamp: 2013-09-12 02:51:59 lastmod: 2021-09-26 22:26:24 status_changed: 2013-09-12 02:51:59 type: article metadata_visibility: show item_issues_count: 0 creators_name: Labbaf, S creators_name: Deb, S creators_name: Cama, G creators_name: Stride, E creators_name: Edirisinghe, M title: Preparation of multicompartment sub-micron particles using a triple-needle electrohydrodynamic device. ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F45 divisions: F52 keywords: Drug delivery, Electrohydrodynamic, Human osteoblast cells, Multilayered structures, Polymer, Sub-micron particles note: ©� 2013 Elsevier Inc. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. abstract: Control over the size and morphology of polymeric carriers for drug delivery systems is essential to optimize their functionality. In the current study, we demonstrate the feasibility of using an electrohydrodynamic process with a triple-needle device to prepare nearly mono-dispersed, spherical, tri-layered sub-micron particles. Three biocompatible polymer solutions of poly (lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL) and polymethylsilsesquioxane (PMSQ) were used to prepare particles with three distinct layers. Optimized particles were shown to be spherical with an average size ranging from 320nm (±80nm) to 220 (±8nm), which varied with a change in the working distance in the electrohydrodynamic processing. The surface and internal structure and morphology were studied using confocal, transmission and scanning electron microscopy combined with focused ion beam sectioning. Cytotoxicity was shown to be negligible in an in vitro assay. The ability to fabricate such multilayered particles in a single step, under ambient conditions has considerable potential for a range of applications in particular controlled release drug delivery system. date: 2013-11-01 official_url: http://dx.doi.org/10.1016/j.jcis.2013.07.033 vfaculties: VENG oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: JOURNAL ARTICLE verified: verified_manual elements_source: PubMed elements_id: 896949 doi: 10.1016/j.jcis.2013.07.033 pii: S0021-9797(13)00674-7 language_elements: ENG lyricists_name: Edirisinghe, Mohan lyricists_name: Labbaf, Sheyda lyricists_name: Stride, Eleanor lyricists_id: MJEDE48 lyricists_id: SLABB33 lyricists_id: EPJST43 full_text_status: public publication: J Colloid Interface Sci volume: 409 pagerange: 245-254 citation: Labbaf, S; Deb, S; Cama, G; Stride, E; Edirisinghe, M; (2013) Preparation of multicompartment sub-micron particles using a triple-needle electrohydrodynamic device. J Colloid Interface Sci , 409 pp. 245-254. 10.1016/j.jcis.2013.07.033 <https://doi.org/10.1016/j.jcis.2013.07.033>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1405322/1/1-s2.0-S0021979713006747-main.pdf