eprintid: 1403815 rev_number: 31 eprint_status: archive userid: 608 dir: disk0/01/40/38/15 datestamp: 2013-09-06 18:53:13 lastmod: 2021-10-10 22:38:16 status_changed: 2013-09-06 18:53:13 type: article metadata_visibility: show item_issues_count: 0 creators_name: Allin, MP creators_name: Kontis, D creators_name: Walshe, M creators_name: Wyatt, J creators_name: Barker, GJ creators_name: Kanaan, RA creators_name: McGuire, P creators_name: Rifkin, L creators_name: Murray, RM creators_name: Nosarti, C title: White matter and cognition in adults who were born preterm ispublished: pub divisions: UCL divisions: B02 divisions: C07 note: © 2011 Allin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. abstract: BACKGROUND AND PURPOSE: Individuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour. METHODS: We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range 17-22 years, respectively). VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed. RESULTS: The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only. CONCLUSIONS: Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function. date: 2011-10-12 official_url: http://dx.doi.org/10.1371/journal.pone.0024525 vfaculties: VFBRS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: JOUR verified: verified_manual elements_source: Manually entered elements_id: 899538 doi: 10.1371/journal.pone.0024525 medium: 10 lyricists_name: Walshe, Muriel lyricists_id: MWALS08 full_text_status: public publication: PLoS One volume: 6 article_number: e24525 pagerange: - issn: 1932-6203 citation: Allin, MP; Kontis, D; Walshe, M; Wyatt, J; Barker, GJ; Kanaan, RA; McGuire, P; ... Nosarti, C; + view all <#> Allin, MP; Kontis, D; Walshe, M; Wyatt, J; Barker, GJ; Kanaan, RA; McGuire, P; Rifkin, L; Murray, RM; Nosarti, C; - view fewer <#> (2011) White matter and cognition in adults who were born preterm. PLoS One , 6 , Article e24525. 10.1371/journal.pone.0024525 <https://doi.org/10.1371/journal.pone.0024525>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1403815/1/journal.pone.0024525.pdf