eprintid: 1403815
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/01/40/38/15
datestamp: 2013-09-06 18:53:13
lastmod: 2021-10-10 22:38:16
status_changed: 2013-09-06 18:53:13
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Allin, MP
creators_name: Kontis, D
creators_name: Walshe, M
creators_name: Wyatt, J
creators_name: Barker, GJ
creators_name: Kanaan, RA
creators_name: McGuire, P
creators_name: Rifkin, L
creators_name: Murray, RM
creators_name: Nosarti, C
title: White matter and cognition in adults who were born preterm
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
note: © 2011 Allin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
abstract: BACKGROUND AND PURPOSE: Individuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour. METHODS: We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range 17-22 years, respectively). VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed. RESULTS: The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only. CONCLUSIONS: Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function.
date: 2011-10-12
official_url: http://dx.doi.org/10.1371/journal.pone.0024525
vfaculties: VFBRS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: JOUR
verified: verified_manual
elements_source: Manually entered
elements_id: 899538
doi: 10.1371/journal.pone.0024525
medium: 10
lyricists_name: Walshe, Muriel
lyricists_id: MWALS08
full_text_status: public
publication: PLoS One
volume: 6
article_number: e24525
pagerange: -
issn: 1932-6203
citation:        Allin, MP;    Kontis, D;    Walshe, M;    Wyatt, J;    Barker, GJ;    Kanaan, RA;    McGuire, P;             ... Nosarti, C; + view all <#>        Allin, MP;  Kontis, D;  Walshe, M;  Wyatt, J;  Barker, GJ;  Kanaan, RA;  McGuire, P;  Rifkin, L;  Murray, RM;  Nosarti, C;   - view fewer <#>    (2011)    White matter and cognition in adults who were born preterm.                   PLoS One , 6     , Article e24525.  10.1371/journal.pone.0024525 <https://doi.org/10.1371/journal.pone.0024525>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1403815/1/journal.pone.0024525.pdf