eprintid: 1402480 rev_number: 60 eprint_status: archive userid: 608 dir: disk0/01/40/24/80 datestamp: 2013-08-22 10:54:19 lastmod: 2021-10-04 01:53:31 status_changed: 2018-06-05 13:22:52 type: article metadata_visibility: show item_issues_count: 0 creators_name: Olivo, A creators_name: Gkoumas, S creators_name: Endrizzi, M creators_name: Hagen, CK creators_name: Szafraniec, MB creators_name: Diemoz, PC creators_name: Munro, PRT creators_name: Ignatyev, K creators_name: Johnson, B creators_name: Horrocks, JA creators_name: Vinnicombe, SJ creators_name: Jones, JL creators_name: Speller, RD title: Low-dose phase contrast mammography with conventional x-ray sources ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F42 keywords: Mammography, x-ray phase contrast imaging, microcalcifications, image contrast note: © 2013 American Association of Physicists in Medicine abstract: Purpose: To provide an x-ray phase contrast imaging (XPCI) method working with conventional sources that could be readily translated into clinical practice. XPCI shows potential in synchrotron studies but attempts at translating it for use with conventional sources are subject to limitations in terms of field of view, stability, exposure time, and possibly most importantly, delivered dose. Methods: Following the adaptation of our “edge-illumination” XPCI technique for use with conventional x-ray sources through the use of x-ray masks, the authors have further modified the design of such masks to allow further reducing the dose delivered to the sample without affecting the phase sensitivity of the method. Results: The authors have built a prototype based on the new mask design and used it to image ex vivo breast tissue samples containing malignant lesions. The authors compared images acquired with this prototype to those obtained with a conventional system. The authors demonstrate and quantify image improvements, especially in terms of microcalcification detection. On calcifications detected also by the conventional system, the authors measure contrast increases from five to nine fold; calcifications and other features were also detected which are completely invisible in the conventional image. Dose measurements confirmed that the above enhancements were achieved while delivering doses compatible with clinical practice. Conclusions: The authors obtained phase-related image enhancements in mammography by means of a system built with components available off-the-shelf that operates under exposure time and dose conditions compatible with clinical practice. This opens the way to a straightforward translation of phase enhanced imaging methods into clinical practice. date: 2016-11-30 publisher: AAPM official_url: http://dx.doi.org/10.1118/1.4817480 vfaculties: VENG oa_status: green language: eng primo: open primo_central: open_green article_type_text: Letter verified: verified_manual elements_source: Manually entered elements_id: 895476 doi: 10.1118/1.4817480 lyricists_name: Diemoz, Paul lyricists_name: Endrizzi, Marco lyricists_name: Hagen, Charlotte lyricists_name: Munro, Peter lyricists_name: Olivo, Alessandro lyricists_name: Speller, Robert lyricists_id: PCDIE01 lyricists_id: MENDR57 lyricists_id: CKHAG69 lyricists_id: PRTMU72 lyricists_id: AOLIV86 lyricists_id: RDSPE08 full_text_status: public publication: Medical Physics volume: 40 number: 9 article_number: 090701 place_of_pub: US pages: 6 event_location: US issn: 0094-2405 citation: Olivo, A; Gkoumas, S; Endrizzi, M; Hagen, CK; Szafraniec, MB; Diemoz, PC; Munro, PRT; ... Speller, RD; + view all <#> Olivo, A; Gkoumas, S; Endrizzi, M; Hagen, CK; Szafraniec, MB; Diemoz, PC; Munro, PRT; Ignatyev, K; Johnson, B; Horrocks, JA; Vinnicombe, SJ; Jones, JL; Speller, RD; - view fewer <#> (2016) Low-dose phase contrast mammography with conventional x-ray sources. Medical Physics , 40 (9) , Article 090701. 10.1118/1.4817480 <https://doi.org/10.1118/1.4817480>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1402480/1/MedPhys2013_Preprint.pdf