eprintid: 1399930
rev_number: 30
eprint_status: archive
userid: 608
dir: disk0/01/39/99/30
datestamp: 2013-07-18 18:44:07
lastmod: 2021-09-19 23:40:43
status_changed: 2013-07-18 18:44:07
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Nightingale, T
creators_name: Cutler, D
title: The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D77
keywords: Rab GTPase, Weibel-Palade bodies, endothelial cells, exocytosis, hemostasis, von Willebrand factor
note: © 2014 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis
This is an open access article under the terms of the Creative Commons Attribution License, which permits use,
distribution and reproduction in any medium, provided the original work is properly cited.
abstract: von Willebrand factor (VWF) plays key roles in both primary and secondary hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is stored within the Weibel-Palade bodies (WPBs) of endothelial cells as a highly prothrombotic protein, and its release is thus necessarily under tight control. Regulating the secretion of VWF involves multiple layers of cellular machinery that act together at different stages, leading to the exocytic fusion of WPBs with the plasma membrane and the consequent release of VWF. This review aims to provide a snapshot of the current understanding of those components, in particular the members of the Rab family, acting in the increasingly complex story of VWF secretion.
date: 2013-06
official_url: http://dx.doi.org/0.1111/jth.12225
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 887276
doi: 10.1111/jth.12225
lyricists_name: Cutler, Daniel
lyricists_id: DFCUT81
full_text_status: public
publication: J Thromb Haemost
volume: 11 Sup
pagerange: 192 - 201
event_location: England
citation:        Nightingale, T;    Cutler, D;      (2013)    The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story.                   J Thromb Haemost , 11 Sup    192 - 201.    10.1111/jth.12225 <https://doi.org/10.1111/jth.12225>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1399930/1/jth12225.pdf