TY - JOUR N1 - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3378479 IS - 3 SP - 516 VL - 22 A1 - Vitureira, N A1 - Letellier, M A1 - Goda, Y JF - Current Opinion in Neurobiology SN - 0959-4388 UR - http://dx.doi.org/10.1016/j.conb.2011.09.006 EP - 521 AV - public Y1 - 2012/06// TI - Homeostatic synaptic plasticity: from single synapses to neural circuits. KW - Animals KW - Homeostasis KW - Nerve Net KW - Neuronal Plasticity KW - Neurons KW - Synapses ID - discovery1399234 N2 - Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the basic properties of homeostatic synaptic plasticity. In this review we address how homeostatic mechanisms balance synaptic strengths between the presynaptic and the postsynaptic terminals and across synapses that share the same postsynaptic neuron. ER -