eprintid: 1396550
rev_number: 39
eprint_status: archive
userid: 608
dir: disk0/01/39/65/50
datestamp: 2013-06-17 18:54:02
lastmod: 2022-01-25 23:32:52
status_changed: 2013-06-17 18:54:02
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Elbaz, A
creators_name: Sabia, S
creators_name: Brunner, E
creators_name: Shipley, M
creators_name: Marmot, M
creators_name: Kivimaki, M
creators_name: Singh-Manoux, A
title: Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study.
ispublished: pub
divisions: UCL
divisions: B02
divisions: D12
divisions: G19
note: © The Author(s) 2012. This article is published with open access at Springerlink.com. This article is distributed under the terms of the
Creative Commons Attribution License which permits any use,
distribution, and reproduction in any medium, provided the
original author(s) and the source are credited.
abstract: Slow walking speed is associated with increased mortality in the elderly, but it is unknown whether a similar association is present in late midlife. Our aim was to examine walking speed in late midlife as a predictor of mortality, as well as factors that may explain this association. Data are drawn from the Whitehall II longitudinal cohort study of British civil servants. The analyses are based on 6,266 participants (29% women; mean age=61 years, SD=6) for whom "walking speed at usual pace" was measured over 8 ft (2.44 m) at baseline. Participants were followed for all-cause and cause-specific mortalities during a mean of 6.4 (SD=0.8) years. During this period, 227 participants died. Participants in the bottom sex-specific third of walking speed (men, <1.26 m/s; women, <1.09 m/s) had an increased risk of death compared to those in the middle and top thirds (age- and sex-adjusted hazard ratio=1.89, 95% confidence interval (CI)01.45-2.46), with no evidence of effect modification by age or sex (interactions, P≥0.40). The association between walking speed and mortality was partially explained by baseline inflammatory markers (percentage reduction of the association 22.8%), height and body mass index (16.6%), chronic diseases (14.0%), and health behaviors (13.4%). Together these and other baseline factors (socioeconomic status, cardiovascular risk factors, cognitive function) explained 48.5% of the association (adjusted hazard ratio=1.39, 95% CI01.04-1.84). In conclusion, walking speed measured in late midlife seems to be an important marker of mortality risk; multiple factors, in particular inflammatory markers, partially explain this association.
date: 2013-06
official_url: http://dx.doi.org/10.1007/s11357-012-9387-9
vfaculties: VFPHS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
verified: verified_manual
elements_source: PubMed
elements_id: 877261
doi: 10.1007/s11357-012-9387-9
lyricists_name: Brunner, Eric
lyricists_name: Kivimaki, Mika
lyricists_name: Sabia, Severine
lyricists_name: Shipley, Martin
lyricists_name: Singh-Manoux, Archana
lyricists_id: EJBRU90
lyricists_id: MJKIV95
lyricists_id: SRSAB69
lyricists_id: MJSHI88
lyricists_id: ASING25
full_text_status: public
publication: Age (Dordr)
volume: 35
number: 3
pagerange: 943 - 952
event_location: Netherlands
citation:        Elbaz, A;    Sabia, S;    Brunner, E;    Shipley, M;    Marmot, M;    Kivimaki, M;    Singh-Manoux, A;      (2013)    Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study.                   Age (Dordr) , 35  (3)   943 - 952.    10.1007/s11357-012-9387-9 <https://doi.org/10.1007/s11357-012-9387-9>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1396550/1/art%253A10.1007%252Fs11357-012-9387-9.pdf