eprintid: 1395037
rev_number: 60
eprint_status: archive
userid: 608
dir: disk0/01/39/50/37
datestamp: 2013-06-01 18:39:21
lastmod: 2021-09-20 22:17:05
status_changed: 2014-02-24 15:01:42
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Kolyva, C
creators_name: Ghosh, A
creators_name: Tachtsidis, I
creators_name: Highton, D
creators_name: Cooper, CE
creators_name: Smith, M
creators_name: Elwell, CE
title: Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: B04
divisions: C05
divisions: F42
keywords: Cytochrome c oxidase;
    Hypoxia;
    Hyperoxia;
    Hypocapnia;
    Hypercapnia;
    Near-infrared spectroscopy;
note: © 2013 The Authors. Published by Elsevier Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction
in any medium, provided the original author and source are credited.
abstract: The redox state of cerebral mitochondrial cytochrome c oxidase monitored with near-infrared spectroscopy (Δ[oxCCO]) is a signal with strong potential as a non-invasive, bedside biomarker of cerebral metabolic status. We hypothesised that the higher mitochondrial density of brain compared to skin and skull would lead to evidence of brain-specificity of the Δ[oxCCO] signal when measured with a multi-distance near-infrared spectroscopy (NIRS) system. Measurements of Δ[oxCCO] as well as of concentration changes in oxygenated (Δ[HbO2]) and deoxygenated haemoglobin (Δ[HHb]) were taken at multiple source-detector distances during systemic hypoxia and hypocapnia (decrease in cerebral oxygen delivery), and hyperoxia and hypercapnia (increase in cerebral oxygen delivery) from 15 adult healthy volunteers. Increasing source-detector spacing is associated with increasing light penetration depth and thus higher sensitivity to cerebral changes. An increase in Δ[oxCCO] was observed during the challenges that increased cerebral oxygen delivery and the opposite was observed when cerebral oxygen delivery decreased. A consistent pattern of statistically significant increasing amplitude of the Δ[oxCCO] response with increasing light penetration depth was observed in all four challenges, a behaviour that was distinctly different from that of the haemoglobin chromophores, which did not show this statistically significant depth gradient. This depth-dependence of the Δ[oxCCO] signal corroborates the notion of higher concentrations of CCO being present in cerebral tissue compared to extracranial components and highlights the value of NIRS-derived Δ[oxCCO] as a brain-specific signal of cerebral metabolism, superior in this aspect to haemoglobin.
date: 2014-01-15
official_url: http://dx.doi.org/10.1016/j.neuroimage.2013.05.070
vfaculties: VFBRS
vfaculties: VENG
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: JOURNAL ARTICLE
verified: verified_manual
elements_source: PubMed
elements_id: 874790
doi: 10.1016/j.neuroimage.2013.05.070
pii: S1053-8119(13)00570-3
language_elements: ENG
lyricists_name: Elwell, Clare
lyricists_name: Ghosh, Arnab
lyricists_name: Highton, David
lyricists_name: Kolyva, Christina
lyricists_name: Smith, Martin
lyricists_name: Tachtsidis, Ilias
lyricists_id: CEELW72
lyricists_id: AGHOS94
lyricists_id: DHIGH82
lyricists_id: CKOLY70
lyricists_id: MSMIT43
lyricists_id: ITACH19
full_text_status: public
publication: Neuroimage
volume: 85
number: 1
pagerange: 234-244
issn: 1053-8119
citation:        Kolyva, C;    Ghosh, A;    Tachtsidis, I;    Highton, D;    Cooper, CE;    Smith, M;    Elwell, CE;      (2014)    Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin.                   Neuroimage , 85  (1)   pp. 234-244.    10.1016/j.neuroimage.2013.05.070 <https://doi.org/10.1016/j.neuroimage.2013.05.070>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1395037/1/1-s2.0-S1053811913005703-main.pdf