eprintid: 1392358
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/01/39/23/58
datestamp: 2013-05-03 18:59:02
lastmod: 2021-11-01 02:06:02
status_changed: 2013-05-03 18:59:02
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: White, AH
creators_name: Smith, FT
title: Computational modelling of the embolization process for the treatment of arteriovenous malformations (AVMs)
ispublished: pub
divisions: UCL
divisions: B04
divisions: C06
divisions: F59
keywords: Arteriovenous malformation, Embolization, Branching, Multiphase, Volume of fluid
note: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
abstract: Arteriovenous malformations (AVMs) are neurological defects in which the arterial and venous systems are connected directly, with no intervening capillaries. The absence of capillaries allows blood at high pressure to enter the venous system directly, and so a venous haemorrhage or a stroke is possible. AVMs can be treated by embolization in which a glue is injected into a local artery with the aim of diverting the blood away from the AVM and so reducing the risk of haemorrhage. The present study introduces a novel mathematical model for the embolization procedure by considering a two-phase fluid dynamical approach for the glue/blood interaction. The two fluids are treated as incompressible and viscous, and their interaction is modelled using the volume-of-fluid method, with the aim of analysing the dynamics of the glue after injection and examining potential blocking strategies. The results obtained here include surface tension effects and point to advantageous placement, blocking and effective solidification in particular.
date: 2013-03
official_url: http://dx.doi.org/10.1016/j.mcm.2012.10.033
vfaculties: VMPS
oa_status: green
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_source: WoS-Lite
elements_id: 838274
doi: 10.1016/j.mcm.2012.10.033
lyricists_name: Smith, Frank
lyricists_id: FTSMI62
full_text_status: public
publication: Mathematical and Computer Modelling
volume: 57
number: 5-6
pagerange: 1312 - 1324
issn: 0895-7177
citation:        White, AH;    Smith, FT;      (2013)    Computational modelling of the embolization process for the treatment of arteriovenous malformations (AVMs).                   Mathematical and Computer Modelling , 57  (5-6)   1312 - 1324.    10.1016/j.mcm.2012.10.033 <https://doi.org/10.1016/j.mcm.2012.10.033>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1392358/1/1392358.pdf