eprintid: 1389213 rev_number: 29 eprint_status: archive userid: 608 dir: disk0/01/38/92/13 datestamp: 2013-04-08 21:25:58 lastmod: 2021-12-10 00:56:32 status_changed: 2013-04-08 21:25:58 type: article metadata_visibility: show item_issues_count: 0 creators_name: Murray, ML creators_name: Insuk, S creators_name: Banaschewski, T creators_name: Neubert, AC creators_name: McCarthy, S creators_name: Buitelaar, JK creators_name: Coghill, D creators_name: Dittmann, RW creators_name: Konrad, K creators_name: Panei, P creators_name: Rosenthal, E creators_name: Sonuga-Barke, EJ creators_name: Wong, ICK title: An inventory of European data sources for the long-term safety evaluation of methylphenidate. ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G11 divisions: D65 divisions: J38 note: This article is available under the terms of the Creative Commons Attribution License (CC BY) as indicated via the Publisher Version link above. abstract: To compile an inventory of European healthcare databases with potential to study long-term effects of methylphenidate (MPH) in patients with attention deficit hyperactivity disorder (ADHD). Potential databases were identified through expert opinion, the website of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, and literature search. An online survey was conducted among database providers/coordinators to ascertain the databases’ appropriateness for inclusion into the inventory. It included questions about database characteristics, sample size, availability of information on drug exposure, clinical data and accessibility. Forty-two databases from 11 countries were identified and their coordinators invited to participate; responses were obtained for 22 (52.4 %) databases of which 15 record ADHD diagnoses. Eleven had sufficient data on ADHD diagnosis, drug exposure, and at least one type of outcome information (symptoms/clinical events, weight, height, blood pressure, heart rate) to assess MPH safety. These were Aarhus University Prescription Database, Danish National Birth Cohort (Denmark); German Health Interview and Examination Survey for Children and Adolescents; Health Search Database Thales, Italian ADHD Register, Lombardy Region ADHD Database (Italy); Avon Longitudinal Study of Parents and Children, General Practice Research Database, The Health Improvement Network, QResearch (UK) and IMS Disease Analyzer (UK, Germany, France). Of the 20 databases with no responses, information on seven from publications and/or websites was obtained; Pedianet and the Integrated Primary Care Information database were considered suitable. Many European healthcare databases can be used for multinational long-term safety studies of MPH. Methodological research is underway to investigate the feasibility of their pooling and analysis. date: 2013-10 official_url: http://dx.doi.org/10.1007/s00787-013-0386-x vfaculties: VFLS oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_source: Manually entered elements_id: 856967 doi: 10.1007/s00787-013-0386-x lyricists_name: Murray, Macey lyricists_name: Wong, Ian lyricists_id: MMURR38 lyricists_id: ICKWO00 full_text_status: public publication: European Child & Adolescent Psychiatry volume: 22 number: 10 pagerange: 605-618 issn: 1018-8827 citation: Murray, ML; Insuk, S; Banaschewski, T; Neubert, AC; McCarthy, S; Buitelaar, JK; Coghill, D; ... Wong, ICK; + view all <#> Murray, ML; Insuk, S; Banaschewski, T; Neubert, AC; McCarthy, S; Buitelaar, JK; Coghill, D; Dittmann, RW; Konrad, K; Panei, P; Rosenthal, E; Sonuga-Barke, EJ; Wong, ICK; - view fewer <#> (2013) An inventory of European data sources for the long-term safety evaluation of methylphenidate. European Child & Adolescent Psychiatry , 22 (10) pp. 605-618. 10.1007/s00787-013-0386-x <https://doi.org/10.1007/s00787-013-0386-x>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1389213/1/art_10.1007_s00787-013-0386-x.pdf