eprintid: 1367875
rev_number: 37
eprint_status: archive
userid: 608
dir: disk0/01/36/78/75
datestamp: 2012-10-15 19:37:30
lastmod: 2020-02-12 21:42:58
status_changed: 2012-12-03 11:15:08
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: ISLAM, S
creators_name: NEIDLE, S
title: NUCLEIC-ACID BINDING-DRUGS .7. MOLECULAR-MECHANICS STUDIES ON THE CONFORMATIONAL PROPERTIES OF THE ANTI-CANCER DRUG DAUNOMYCIN - SOME OBSERVATIONS ON THE USE OF DIFFERING POTENTIAL-ENERGY FUNCTIONS
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C08
divisions: D10
note: Copyright © International Union of Crystallography
abstract: The conformation of the anti-cancer drug daunomycin
has been investigated in detail by potential-energy
calculations. The flexibility around the ether linkage,
connecting the anthracycline chromophore and the
amino sugar group, has been evaluated using several
types of potential-energy function. The results largely
support the hypothesis that the crystallographically
observed conformation is the most stable one, although
considerable detailed variation with respect to potential
function was found.
date: 1983-02
official_url: http://scripts.iucr.org/cgi-bin/paper?S0108768183002098
vfaculties: VFLS
oa_status: green
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_source: WoS-Lite
elements_id: 421224
doi: 10.1107/S0108768183002098
lyricists_name: Neidle, Stephen
lyricists_id: SNEID18
full_text_status: public
publication: ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE
volume: 39
number: Part 1
pagerange: 114 - 119
issn: 0108-7681
citation:        ISLAM, S;    NEIDLE, S;      (1983)    NUCLEIC-ACID BINDING-DRUGS .7. MOLECULAR-MECHANICS STUDIES ON THE CONFORMATIONAL PROPERTIES OF THE ANTI-CANCER DRUG DAUNOMYCIN - SOME OBSERVATIONS ON THE USE OF DIFFERING POTENTIAL-ENERGY FUNCTIONS.                   ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE , 39  (Part 1)   114 - 119.    10.1107/S0108768183002098 <https://doi.org/10.1107/S0108768183002098>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1367875/1/a22080.pdf