eprintid: 1361523 rev_number: 65 eprint_status: archive userid: 608 dir: disk0/01/36/15/23 datestamp: 2012-09-14 18:34:48 lastmod: 2021-09-25 22:52:56 status_changed: 2012-09-14 18:34:48 type: article metadata_visibility: show item_issues_count: 0 creators_name: Ghosh, A creators_name: Tachtsidis, I creators_name: Kolyva, C creators_name: Highton, D creators_name: Elwell, C creators_name: Smith, M title: Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: B04 divisions: C05 divisions: F42 keywords: Adult, Aged, Brain Injuries, Cerebrovascular Circulation, Electron Transport Complex IV, Female, Hemoglobins, Humans, Hyperoxia, Lactic Acid, Male, Middle Aged, Monitoring, Physiologic, Oxidation-Reduction, Oxygen, Oxyhemoglobins, Pyruvic Acid, Spectroscopy, Near-Infrared, Young Adult note: © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. abstract: We report the use of a novel hybrid near-infrared spectrometer for the measurement of optical scattering, pathlength and chromophore concentration in critically ill patients with brain injury. Ten mechanically ventilated patients with acute brain injury were studied. In addition to standard neurointensive care monitoring, middle cerebral artery flow velocity, brain lactate-pyruvate ratio (LPR) and brain tissue oxygen tension were monitored. The patients were subjected to graded normobaric hyperoxia (NBH), with the inspired fraction of oxygen increased from baseline to 60% then 100%. NBH induced significant changes in the concentrations of oxyhaemoglobin, deoxyhaemoglobin and oxidised-reduced cytochrome c oxidase; these were accompanied by a corresponding reduction in brain LPR and increase in brain tissue oxygen tension. No significant change in optical scattering or pathlength was observed. These results suggest that the measurement of chromophore concentration in the injured brain is not confounded by changes in optical scattering or pathlength and that NBH induces an increase in cerebral aerobic metabolism. date: 2013 official_url: http://dx.doi.org/10.1007/978-1-4614-4989-8_10 vfaculties: VFBRS vfaculties: VENG oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article, Research Support, Non-U.S. Gov't verified: verified_manual elements_source: PubMed elements_id: 438929 doi: 10.1007/978-1-4614-4989-8_10 lyricists_name: Elwell, Clare lyricists_name: Ghosh, Arnab lyricists_name: Highton, David lyricists_name: Kolyva, Christina lyricists_name: Smith, Martin lyricists_name: Tachtsidis, Ilias lyricists_id: CEELW72 lyricists_id: AGHOS94 lyricists_id: DHIGH82 lyricists_id: CKOLY70 lyricists_id: MSMIT43 lyricists_id: ITACH19 full_text_status: public publication: Adv Exp Med Biol volume: 765 pagerange: 67 - 72 event_location: United States issn: 0065-2598 citation: Ghosh, A; Tachtsidis, I; Kolyva, C; Highton, D; Elwell, C; Smith, M; (2013) Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury. Adv Exp Med Biol , 765 67 - 72. 10.1007/978-1-4614-4989-8_10 <https://doi.org/10.1007/978-1-4614-4989-8_10>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1361523/1/chp_10.1007_978-1-4614-4989-8_10.pdf