eprintid: 1361523
rev_number: 65
eprint_status: archive
userid: 608
dir: disk0/01/36/15/23
datestamp: 2012-09-14 18:34:48
lastmod: 2021-09-25 22:52:56
status_changed: 2012-09-14 18:34:48
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Ghosh, A
creators_name: Tachtsidis, I
creators_name: Kolyva, C
creators_name: Highton, D
creators_name: Elwell, C
creators_name: Smith, M
title: Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: B04
divisions: C05
divisions: F42
keywords: Adult, Aged, Brain Injuries, Cerebrovascular Circulation, Electron Transport Complex IV, Female, Hemoglobins, Humans, Hyperoxia, Lactic Acid, Male, Middle Aged, Monitoring, Physiologic, Oxidation-Reduction, Oxygen, Oxyhemoglobins, Pyruvic Acid, Spectroscopy, Near-Infrared, Young Adult
note: © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
abstract: We report the use of a novel hybrid near-infrared spectrometer for the measurement of optical scattering, pathlength and chromophore concentration in critically ill patients with brain injury. Ten mechanically ventilated patients with acute brain injury were studied. In addition to standard neurointensive care monitoring, middle cerebral artery flow velocity, brain lactate-pyruvate ratio (LPR) and brain tissue oxygen tension were monitored. The patients were subjected to graded normobaric hyperoxia (NBH), with the inspired fraction of oxygen increased from baseline to 60% then 100%. NBH induced significant changes in the concentrations of oxyhaemoglobin, deoxyhaemoglobin and oxidised-reduced cytochrome c oxidase; these were accompanied by a corresponding reduction in brain LPR and increase in brain tissue oxygen tension. No significant change in optical scattering or pathlength was observed. These results suggest that the measurement of chromophore concentration in the injured brain is not confounded by changes in optical scattering or pathlength and that NBH induces an increase in cerebral aerobic metabolism.
date: 2013
official_url: http://dx.doi.org/10.1007/978-1-4614-4989-8_10
vfaculties: VFBRS
vfaculties: VENG
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Research Support, Non-U.S. Gov't
verified: verified_manual
elements_source: PubMed
elements_id: 438929
doi: 10.1007/978-1-4614-4989-8_10
lyricists_name: Elwell, Clare
lyricists_name: Ghosh, Arnab
lyricists_name: Highton, David
lyricists_name: Kolyva, Christina
lyricists_name: Smith, Martin
lyricists_name: Tachtsidis, Ilias
lyricists_id: CEELW72
lyricists_id: AGHOS94
lyricists_id: DHIGH82
lyricists_id: CKOLY70
lyricists_id: MSMIT43
lyricists_id: ITACH19
full_text_status: public
publication: Adv Exp Med Biol
volume: 765
pagerange: 67 - 72
event_location: United States
issn: 0065-2598
citation:        Ghosh, A;    Tachtsidis, I;    Kolyva, C;    Highton, D;    Elwell, C;    Smith, M;      (2013)    Normobaric hyperoxia does not change optical scattering or pathlength but does increase oxidised cytochrome C oxidase concentration in patients with brain injury.                   Adv Exp Med Biol , 765    67 - 72.    10.1007/978-1-4614-4989-8_10 <https://doi.org/10.1007/978-1-4614-4989-8_10>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1361523/1/chp_10.1007_978-1-4614-4989-8_10.pdf