<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1349311> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/dc/terms/title> "Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/ontology/bibo/abstract> "Ischemic white matter injury has been relatively little studied despite its importance to the outcome of stroke. To aid such research a new rat model has been developed in vivo and used to assess whether blockade of the sodium/calcium exchanger is effective in protecting central axons from ischemic injury. Vasoconstrictive agent endothelin-1 was injected into the rat spinal cord to induce ischemia. KB-R7943 or SEA0400 was administered systemically to block the operation of the sodium/calcium exchanger. Endothelin-1 caused profound reduction of local blood perfusion and resulted in a prompt loss of axonal conduction. Whereas recovery of conduction following vehicle administration was only to 10.5 ± 9% of baseline (n = 8) 4.5 h after endothelin-1 injection, recovery following KB-R7943 (30 mg/kg, i.a.) administration was increased to 35 ± 9% of baseline (n = 6; P < 0.001). SEA0400 (30 mg/kg, i.a.) was also protective (33.2 ± 6% of baseline, n = 4; P < 0.001). Neither drug improved conduction by diminishing the severity of the ischemia. The protective effect of KB-R7943 persisted for at least 3 days after ischemia, as it improved axonal conduction (76.3 ± 11% for KB-R7943 vs. 51.0 ± 19% for vehicle; P < 0.01) and reduced lesion area (55.6 ± 15% for KB-R7943 vs. 77.9 ± 9% for vehicle; P < 0.01) at this time. In conclusion, a new model of white matter ischemia has been introduced suitable for both structural and functional studies in vivo. Blocking the sodium/calcium exchanger protects central axons from ischemic injury in vivo."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/dc/terms/date> "2012-09" .
<https://discovery.ucl.ac.uk/id/document/45044> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/ontology/bibo/volume> "63" .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/ontology/bibo/issue> "3" .
<https://discovery.ucl.ac.uk/id/publication/ext-73d00e65ac7fbdaaef0d9d3f66aef0f8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-73d00e65ac7fbdaaef0d9d3f66aef0f8> <http://xmlns.com/foaf/0.1/name> "Neuropharmacology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-73d00e65ac7fbdaaef0d9d3f66aef0f8> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-546f51f79b9f94c9e300b4a1ff40e731> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1349311#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1349311#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-546f51f79b9f94c9e300b4a1ff40e731> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a358523e8a03da2106d2c49e3c3ab309> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1349311#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1349311#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-a358523e8a03da2106d2c49e3c3ab309> .
<https://discovery.ucl.ac.uk/id/person/ext-546f51f79b9f94c9e300b4a1ff40e731> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-546f51f79b9f94c9e300b4a1ff40e731> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-546f51f79b9f94c9e300b4a1ff40e731> <http://xmlns.com/foaf/0.1/familyName> "Bei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-546f51f79b9f94c9e300b4a1ff40e731> <http://xmlns.com/foaf/0.1/name> "F Bei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a358523e8a03da2106d2c49e3c3ab309> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a358523e8a03da2106d2c49e3c3ab309> <http://xmlns.com/foaf/0.1/givenName> "KJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a358523e8a03da2106d2c49e3c3ab309> <http://xmlns.com/foaf/0.1/familyName> "Smith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a358523e8a03da2106d2c49e3c3ab309> <http://xmlns.com/foaf/0.1/name> "KJ Smith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://www.w3.org/2000/01/rdf-schema#label> "Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo. (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://eprints.org/relation/hasVolatileVersion> <https://discovery.ucl.ac.uk/id/document/89160> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://eprints.org/relation/haspreviewThumbnailVersion> <https://discovery.ucl.ac.uk/id/document/89160> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://eprints.org/relation/hasVersion> <https://discovery.ucl.ac.uk/id/document/89160> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1349311/1/1349311.pdf> .
<https://discovery.ucl.ac.uk/id/document/45044> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1349311/1/1349311.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/1349311/1/1349311.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "1349311.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/89160> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://www.w3.org/2000/01/rdf-schema#label> "Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo. (Image (PNG))"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1349311/2/preview.png> .
<https://discovery.ucl.ac.uk/id/document/89160> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1349311/2/preview.png> .
<https://discovery.ucl.ac.uk/id/eprint/1349311/2/preview.png> <http://www.w3.org/2000/01/rdf-schema#label> "preview.png"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/114888> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://www.w3.org/2000/01/rdf-schema#label> "Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo. (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/45044> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1349311/3/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/document/114888> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1349311/3/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/eprint/1349311/3/indexcodes.txt> <http://www.w3.org/2000/01/rdf-schema#label> "indexcodes.txt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1349311> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/1349311/> .
<https://discovery.ucl.ac.uk/id/eprint/1349311/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #1349311 \n\nAxonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo.\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/1349311/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/1349311/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1349311> .