TY  - JOUR
ID  - discovery1347346
N2  - Mitochondria are being recognized as key factors in many unexpected areas of biomedical science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it is now clear that mitochondria are also central to cell death, neoplasia, cell differentiation, the innate immune system, oxygen and hypoxia sensing, and calcium metabolism. Disruption to these processes contributes to a range of human pathologies, making mitochondria a potentially important, but currently seemingly neglected, therapeutic target. Mitochondrial dysfunction is often associated with oxidative damage, calcium dyshomeostasis, defective ATP synthesis, or induction of the permeability transition pore. Consequently, therapies designed to prevent these types of damage are beneficial and can be used to treat many diverse and apparently unrelated indications. Here we outline the biological properties that make mitochondria important determinants of health and disease, and describe the pharmacological strategies being developed to address mitochondrial dysfunction.
KW  - Apoptosis
KW  -  Calcium
KW  -  Drug Discovery
KW  -  Humans
KW  -  Mitochondria
KW  -  Mitochondrial Diseases
KW  -  Mitochondrial Proteins
KW  -  Molecular Targeted Therapy
KW  -  Oxidative Phosphorylation
KW  -  Protective Agents
KW  -  Reactive Oxygen Species
EP  -  352
AV  - public
Y1  - 2012/06//
TI  - Mitochondrial pharmacology.
SN  - 0165-6147
UR  - http://dx.doi.org/10.1016/j.tips.2012.03.010
A1  - Smith, RA
A1  - Hartley, RC
A1  - Cochemé, HM
A1  - Murphy, MP
JF  - Trends in Pharmacological Sciences
VL  - 33
SP  - 341 
N1  - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
IS  - 6
ER  -