eprintid: 1341362
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/01/34/13/62
datestamp: 2012-03-01 20:51:11
lastmod: 2021-09-19 23:12:49
status_changed: 2012-03-01 20:51:11
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Handel, AE
creators_name: Williamson, AJ
creators_name: Disanto, G
creators_name: Handunnetthi, L
creators_name: Giovannoni, G
creators_name: Ramagopalan, SV
title: An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
keywords: EPSTEIN-BARR-VIRUS, CHLAMYDIA-PNEUMONIAE, ASSOCIATION, MS, ANTIBODIES, AGE
note: © 2010 Handel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This work was funded by the Wellcome Trust [GRANT NUMBER 075491/Z/04] and Medical Research Council [GRANT NUMBER G0801976]. SVR is a Goodger Scholar at the University of Oxford. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
abstract: Background: Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published.Methods/Principal Findings: We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97-2.39; p<10(-54)).Discussion: Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis. Future work should focus on the mechanism of this association and interaction with other risk factors.
date: 2010-09-01
publisher: PUBLIC LIBRARY SCIENCE
official_url: http://dx.doi.org/10.1371/journal.pone.0012496
vfaculties: VFBRS
oa_status: green
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_source: Web of Science
elements_id: 256599
doi: 10.1371/journal.pone.0012496
language_elements: EN
lyricists_name: Giovannoni, Gavin
lyricists_id: GGIOV63
full_text_status: public
publication: PLOS ONE
volume: 5
number: 9
article_number: e12496
issn: 1932-6203
citation:        Handel, AE;    Williamson, AJ;    Disanto, G;    Handunnetthi, L;    Giovannoni, G;    Ramagopalan, SV;      (2010)    An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis.                   PLOS ONE , 5  (9)    , Article e12496.  10.1371/journal.pone.0012496 <https://doi.org/10.1371/journal.pone.0012496>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1341362/1/1341362.pdf