<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1341362> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/title> "An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/abstract> "Background: Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published.Methods/Principal Findings: We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97-2.39; p<10(-54)).Discussion: Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis. Future work should focus on the mechanism of this association and interaction with other risk factors."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/date> "2010-09-01" . <https://discovery.ucl.ac.uk/id/document/40026> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/volume> "5" . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/issue> "9" . <https://discovery.ucl.ac.uk/id/org/ext-75ea6aaed5eb22783511e404c3474352> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-75ea6aaed5eb22783511e404c3474352> <http://xmlns.com/foaf/0.1/name> "PUBLIC LIBRARY SCIENCE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-75ea6aaed5eb22783511e404c3474352> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://xmlns.com/foaf/0.1/name> "PLOS ONE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-19326203> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:19326203> . <https://discovery.ucl.ac.uk/id/publication/ext-19326203> <http://purl.org/ontology/bibo/issn> "19326203" . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b2d86e1aa261e9e7e77a159ba4367b2f> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> . <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-b2d86e1aa261e9e7e77a159ba4367b2f> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a82e576ae8c579611a76e8fa1a43068d> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> . <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-a82e576ae8c579611a76e8fa1a43068d> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e521e49d98fdd64eabba20fff269da3b> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> . <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-e521e49d98fdd64eabba20fff269da3b> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-14908d3a73556fb13b4af883a9b40f0f> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> . <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-14908d3a73556fb13b4af883a9b40f0f> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a7aa490240c89ac48065543483e6cd3c> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> . <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a7aa490240c89ac48065543483e6cd3c> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e74c8b89aeaa8db7cb20b5f016ebd2c3> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> . <https://discovery.ucl.ac.uk/id/eprint/1341362#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-e74c8b89aeaa8db7cb20b5f016ebd2c3> . <https://discovery.ucl.ac.uk/id/person/ext-a82e576ae8c579611a76e8fa1a43068d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a82e576ae8c579611a76e8fa1a43068d> <http://xmlns.com/foaf/0.1/givenName> "AJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a82e576ae8c579611a76e8fa1a43068d> <http://xmlns.com/foaf/0.1/familyName> "Williamson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a82e576ae8c579611a76e8fa1a43068d> <http://xmlns.com/foaf/0.1/name> "AJ Williamson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e521e49d98fdd64eabba20fff269da3b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e521e49d98fdd64eabba20fff269da3b> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e521e49d98fdd64eabba20fff269da3b> <http://xmlns.com/foaf/0.1/familyName> "Disanto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e521e49d98fdd64eabba20fff269da3b> <http://xmlns.com/foaf/0.1/name> "G Disanto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e74c8b89aeaa8db7cb20b5f016ebd2c3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e74c8b89aeaa8db7cb20b5f016ebd2c3> <http://xmlns.com/foaf/0.1/givenName> "SV"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e74c8b89aeaa8db7cb20b5f016ebd2c3> <http://xmlns.com/foaf/0.1/familyName> "Ramagopalan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e74c8b89aeaa8db7cb20b5f016ebd2c3> <http://xmlns.com/foaf/0.1/name> "SV Ramagopalan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-14908d3a73556fb13b4af883a9b40f0f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-14908d3a73556fb13b4af883a9b40f0f> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-14908d3a73556fb13b4af883a9b40f0f> <http://xmlns.com/foaf/0.1/familyName> "Handunnetthi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-14908d3a73556fb13b4af883a9b40f0f> <http://xmlns.com/foaf/0.1/name> "L Handunnetthi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7aa490240c89ac48065543483e6cd3c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a7aa490240c89ac48065543483e6cd3c> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7aa490240c89ac48065543483e6cd3c> <http://xmlns.com/foaf/0.1/familyName> "Giovannoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7aa490240c89ac48065543483e6cd3c> <http://xmlns.com/foaf/0.1/name> "G Giovannoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b2d86e1aa261e9e7e77a159ba4367b2f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b2d86e1aa261e9e7e77a159ba4367b2f> <http://xmlns.com/foaf/0.1/givenName> "AE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b2d86e1aa261e9e7e77a159ba4367b2f> <http://xmlns.com/foaf/0.1/familyName> "Handel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b2d86e1aa261e9e7e77a159ba4367b2f> <http://xmlns.com/foaf/0.1/name> "AE Handel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/40026> . <https://discovery.ucl.ac.uk/id/document/40026> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/40026> <http://www.w3.org/2000/01/rdf-schema#label> "An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/40026> <http://eprints.org/relation/hasVolatileVersion> <https://discovery.ucl.ac.uk/id/document/88523> . <https://discovery.ucl.ac.uk/id/document/40026> <http://eprints.org/relation/haspreviewThumbnailVersion> <https://discovery.ucl.ac.uk/id/document/88523> . <https://discovery.ucl.ac.uk/id/document/40026> <http://eprints.org/relation/hasVersion> <https://discovery.ucl.ac.uk/id/document/88523> . <https://discovery.ucl.ac.uk/id/document/40026> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1341362/1/1341362.pdf> . <https://discovery.ucl.ac.uk/id/document/40026> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1341362/1/1341362.pdf> . <https://discovery.ucl.ac.uk/id/eprint/1341362/1/1341362.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "1341362.pdf"^^<http://www.w3.org/2001/XMLSchema#string> . 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<https://discovery.ucl.ac.uk/id/document/88523> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1341362/2/preview.png> . <https://discovery.ucl.ac.uk/id/document/88523> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1341362/2/preview.png> . <https://discovery.ucl.ac.uk/id/eprint/1341362/2/preview.png> <http://www.w3.org/2000/01/rdf-schema#label> "preview.png"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/1341362> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/114144> . <https://discovery.ucl.ac.uk/id/document/114144> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/114144> <http://www.w3.org/2000/01/rdf-schema#label> "An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . 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