TY  - UNPB
N1  - Unpublished
Y1  - 2011/10//
AV  - public
EP  - 235
TI  - A novel wearable electronic device for treating neurogenic detrusor overactivity by conditional neuromodulation
A1  - Edirisinghe, N.A.
M1  - Masters
UR  - https://discovery.ucl.ac.uk/id/eprint/1332894/
PB  - UCL (University College London)
N2  - Urinary incontinence is the involuntary leakage of urine and affects one in twenty
of the population across all ages leading to poor quality of life and can be very
high cost to the nation. It is possible to reduce these costs by accurate diagnosis
and appropriate management of the condition. Urinary incontinence is often
associated with an overactive bladder or urethral sphincter weakness, or both as a
result of interrupting the pathway to nervous communication between the brain
and the bladder leading to uncoordinated activity in the lower urinary tract.
Treatment options for overactive bladder include antimuscarinic drugs and
implanted electrical stimulators. However these drugs have intolerable side
effects, while implanting a stimulator is a surgical procedure which is associated
with degree of risk and becomes ineffective due to habituation to the continuous
stimulation.
The aim of the research was to develop a novel wearable anal device designed to
deliver conditional neuromodulation. The device detects the electromyography
activity in the lower urinary tract, and provides the transrectal stimulation to the
Pudendal nerve when required, in order to suppress the bladder contractions while
contracting the urethral sphincters.
The clinical study included designing and manufacturing patient compatible
model and conducting a clinical study to measure the safety and the efficacy of
the device. Electronics circuit design included amplifier, signal processing
system and constant current stimulator based on the specification derived from
the clinical study and finally focused on optimisation of the device electrodes for
improving stimulating parameters.
ID  - discovery1332894
ER  -