eprintid: 1327402
rev_number: 52
eprint_status: archive
userid: 608
dir: disk0/01/32/74/02
datestamp: 2011-10-28 11:42:33
lastmod: 2022-01-10 00:03:00
status_changed: 2011-10-28 11:42:33
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Perel, P
creators_name: Miranda, JJ
creators_name: Ortiz, Z
creators_name: Casas, JP
title: Relation between the Global Burden of Disease and Randomized Clinical Trials Conducted in Latin America Published in the Five Leading Medical Journals
ispublished: pub
divisions: UCL
divisions: B02
divisions: DD4
note: © 2008 Perel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
JJM is supported by a Wellcome Trust Research Training Fellowship (GR074833MA). The authors have no additional support or funding to report.
abstract: Background: Since 1990 non communicable diseases and injuries account for the majority of death and disability-adjusted life years in Latin America. We analyzed the relationship between the global burden of disease and Randomized Clinical Trials (RCTs) conducted in Latin America that were published in the five leading medical journals.Methodology/Principal Findings: We included all RCTs in humans, exclusively conducted in Latin American countries, and published in any of the following journals: Annals of Internal Medicine, British Medical Journal, Journal of the American Medical Association, Lancet, and New England Journal of Medicine. We described the trials and reported the number of RCTs according to the main categories of the global burden of disease. Sixty-six RCTs were identified. Communicable diseases accounted for 38 (57%) reports. Maternal, perinatal, and nutritional conditions accounted for 19 (29%) trials. Non-communicable diseases represent 48% of the global burden of disease but only 14% of reported trials. No trial addressed injuries despite its 18% contribution to the burden of disease in 2000.Conclusions/Significance: A poor correlation between the burden of disease and RCTs publications was found. Non communicable diseases and injuries account for up to two thirds of the burden of disease in Latin America but these topics are seldom addressed in published RCTs in the selected sample of journals. Funding bodies of health research and editors should be aware of the increasing burden of non communicable diseases and injuries occurring in Latin America to ensure that this growing epidemic is not neglected in the research agenda and not affected by publication bias.
date: 2008-02-27
publisher: PUBLIC LIBRARY SCIENCE
official_url: http://dx.doi.org/10.1371/journal.pone.0001696
vfaculties: VFPHS
oa_status: green
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_batch
elements_source: Web of Science
elements_id: 347453
doi: 10.1371/journal.pone.0001696
language_elements: EN
lyricists_name: Casas Romero, Juan
lyricists_id: JPCAS59
full_text_status: public
publication: PLOS ONE
volume: 3
number: 2
article_number: e1696
issn: 1932-6203
citation:        Perel, P;    Miranda, JJ;    Ortiz, Z;    Casas, JP;      (2008)    Relation between the Global Burden of Disease and Randomized Clinical Trials Conducted in Latin America Published in the Five Leading Medical Journals.                   PLOS ONE , 3  (2)    , Article e1696.  10.1371/journal.pone.0001696 <https://doi.org/10.1371/journal.pone.0001696>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1327402/1/1327402.pdf