eprintid: 1318580
rev_number: 36
eprint_status: archive
userid: 608
dir: disk0/01/31/85/80
datestamp: 2011-09-08 03:48:53
lastmod: 2020-02-22 03:52:27
status_changed: 2011-09-08 03:48:53
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Salvini, S
creators_name: Sera, F
creators_name: Caruso, D
creators_name: Giovannelli, L
creators_name: Visioli, F
creators_name: Saieva, C
creators_name: Masala, G
creators_name: Ceroti, M
creators_name: Giovacchini, V
creators_name: Pitozzi, V
creators_name: Galli, C
creators_name: Romani, A
creators_name: Mulinacci, N
creators_name: Bortolomeazzi, R
creators_name: Dolara, P
creators_name: Palli, D
title: Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women
ispublished: pub
divisions: UCL
keywords: extra-virgin olive oil, phenols, hydroxytyrosol, oxidative DNA damage, cancer, DENSITY-LIPOPROTEIN OXIDATION, BREAST-CANCER RISK, ANTIOXIDANT CAPACITY, FOOD GROUPS, IN-VITRO, HUMANS, DIET, HYDROXYTYROSOL, EXCRETION, CELLS
note: Copyright © The Nutrition Society 2006
abstract: Extra-virgin olive oils (EVOO), high in phenolic compounds with antioxidant properties, could be partly responsible for the lower mortality and incidence of cancer and CVD in the Mediterranean region. The present study aims to measure oxidative DNA damage in healthy human subjects consuming olive oils with different concentrations of natural phenols. A randomised cross-over trial of high-phenol EVOO (high-EVOO; 592 mg total phenols/kg) v. low-phenol EVOO (low-EVOO; 147 mg/kg) was conducted in ten postmenopausal women in Florence. Subjects were asked to substitute all types of fat and oils habitually consumed with the study oil (50 g/d) for 8 weeks in each period. Oxidative DNA damage was measured by the comet assay in peripheral blood lymphocytes, collected at each visit during the study period. Urine samples over 24 h were collected to measure the excretion of the olive oil phenols. The average of the four measurements of oxidative DNA damage during treatment with high-EVOO was 30 % lower than the average during the low-EVOO treatment (P=0.02). Urinary excretion of hydroxytyrosol and its metabolite homovanillyl alcohol were significantly increased in subjects consuming high-EVOO. Despite the small sample size, the present study showed a reduction of DNA damage by consumption of an EVOO rich in phenols, particularly hydroxytyrosol.
date: 2006-04
publisher: CABI PUBLISHING
official_url: http://dx.doi.org/10.1079/BJN20051674
oa_status: green
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_source: Web of Science
elements_id: 335778
doi: 10.1079/BJN20051674
language_elements: EN
lyricists_name: Sera, Francesco
lyricists_id: FSERA63
full_text_status: public
publication: BRIT J NUTR
volume: 95
number: 4
pagerange: 742 - 751
issn: 0007-1145
citation:        Salvini, S;    Sera, F;    Caruso, D;    Giovannelli, L;    Visioli, F;    Saieva, C;    Masala, G;                                     ... Palli, D; + view all <#>        Salvini, S;  Sera, F;  Caruso, D;  Giovannelli, L;  Visioli, F;  Saieva, C;  Masala, G;  Ceroti, M;  Giovacchini, V;  Pitozzi, V;  Galli, C;  Romani, A;  Mulinacci, N;  Bortolomeazzi, R;  Dolara, P;  Palli, D;   - view fewer <#>    (2006)    Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women.                   BRIT J NUTR , 95  (4)   742 - 751.    10.1079/BJN20051674 <https://doi.org/10.1079/BJN20051674>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1318580/1/download24.pdf