eprintid: 1311081
rev_number: 34
eprint_status: archive
userid: 608
dir: disk0/01/31/10/81
datestamp: 2011-06-19 20:44:43
lastmod: 2021-09-19 23:07:43
status_changed: 2013-11-14 11:48:31
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Burnstock, G
title: Purinergic signalling: past, present and future
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
keywords: Purinoceptors P1, P2X, P2Y, ATP release and breakdown, Purinergic neuropathology, Pain, Neurodegenerative diseases, CENTRAL-NERVOUS-SYSTEM, GATED ION CHANNELS, GUINEA-PIG, ATP RECEPTOR, ADENOSINE TRIPHOSPHATE, EXTRACELLULAR ATP, TAENIA-COLI, SYNAPTIC TRANSMISSION, MAMMALIAN NEURONS, STRUCTURAL MOTIF
note: This work is published under a Creative Commons Attribution License (CC-BY). The authors retain ownership of the copyright for their article and can allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
abstract: The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's. The concept of purinergic cotransmission was formulated in 1976 and it is now recognized that ATP is a cotransmitter in all nerves in the peripheral and central nervous systems. Two families of receptors to purines were recognized in 1978, P1 ( adenosine) receptors and P2 receptors sensitive to ATP and adenosine diphosphate ( ADP). Cloning of these receptors in the early 1990's was a turning point in the acceptance of the purinergic signalling hypothesis and there are currently 4 subtypes of P1 receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of G protein-coupled receptors. Both short-term purinergic signalling in neurotransmission, neuromodulation and neurosecretion and long-term ( trophic) purinergic signalling of cell proliferation, differentiation, motility, death in development and regeneration are recognized. There is now much known about the mechanisms underlying ATP release and extracellular breakdown by ecto-nucleotidases. The recent emphasis on purinergic neuropathology is discussed, including changes in purinergic cotransmission in development and ageing and in bladder diseases and hypertension. The involvement of neuron-glial cell interactions in various diseases of the central nervous system, including neuropathic pain, trauma and ischemia, neurodegenerative diseases, neuropsychiatric disorders and epilepsy are also considered.
date: 2009-01
publisher: ASSOC BRAS DIVULG CIENTIFICA
official_url: http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso
vfaculties: VFLS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Proceedings Paper
verified: verified_batch
elements_source: Web of Science
elements_id: 318540
language_elements: EN
lyricists_name: Burnstock, Geoffrey
lyricists_id: GBURN46
full_text_status: public
publication: Brazilian Journal of Medical and Biological Research
volume: 42
number: 1
pagerange: 3-8
event_location: Ribeirao Preto, BRAZIL
issn: 0100-879X
citation:        Burnstock, G;      (2009)    Purinergic signalling: past, present and future.                   Brazilian Journal of Medical and Biological Research , 42  (1)   pp. 3-8.          Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1311081/1/7400.pdf