TY - JOUR SP - 4428 VL - 120 N1 - © 2004 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in Ford, IJ; Harris, SA; (2004) Molecular cluster decay viewed as escape from a potential of mean force. Journal of Chemical Physics , 120 (9) 4428 - 4440. and may be found at http://dx.doi.org/10.1063/1.1644533. IS - 9 SN - 0021-9606 UR - http://dx.doi.org/10.1063/1.1644533 A1 - Ford, IJ A1 - Harris, SA JF - Journal of Chemical Physics EP - 4440 AV - public Y1 - 2004/03/01/ TI - Molecular cluster decay viewed as escape from a potential of mean force PB - AMER INST PHYSICS ID - discovery123680 N2 - We show that evaporation from a quasistable molecular cluster may be treated as a kinetic problem involving the stochastically driven escape of a molecule from a potential of mean force. We derive expressions for the decay rate, and a relationship between the depth of the potential and the change in system free energy upon loss of a molecule from the cluster. This establishes a connection between kinetic and thermodynamic treatments of evaporation, but also reveals differences in the prefactor in the rate expression. We perform constant energy molecular dynamics simulations of cluster dynamics to calculate potentials of mean force, friction coefficients and effective temperatures for use in the kinetic analysis, and to compare the results with the directly observed escape rates. We also use the simulations to estimate the escape rates by a probabilistic analysis. It is much more efficient to calculate the decay rate by the methods we have developed than it is to monitor escape directly, making these approaches potentially useful for the assessment of molecular cluster stability. (C) 2004 American Institute of Physics. KW - Monte-Carlo-simulation KW - homogeneous nucleation rate KW - vapor-liquid nucleation KW - physical clusters KW - equilibrium KW - definition KW - transition KW - gases KW - water ER -